Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982496 | 0.72 | GSK3B (0.45) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4384546 | 0.70 | MAPT (0.49) | RECQLMAPTMEN1KMT2ANPC1 | |
| SCHEMBL5759364 | 0.67 | TDP1 (0.33) | — | |
| SCHEMBL5164166 | 0.66 | RAB9A (0.37) | RECQLMAPTMEN1KMT2ANPC1 | |
| SCHEMBL11848005 | 0.65 | ALDH1A1 (0.44) | TSHRMAPTMEN1KMT2ANPC1 | |
| SCHEMBL5763247 | 0.65 | TDP1 (0.37) | CYP2C9CYP2C19MAPTMEN1KMT2A | |
| SCHEMBL3411109 | 0.64 | POLB (0.44) | TSHRMAPTALDH1A1LMNA | |
| SCHEMBL287087 | 0.64 | ALDH1A1 (0.57) | TSHRMAPTMEN1KMT2ANPC1 | |
| SCHEMBL248005 | 0.64 | SMN1; SMN2 (0.43) | TSHRMAPTMEN1KMT2ANPC1 | |
| SCHEMBL13267370 | 0.64 | ALDH1A1 (0.38) | TSHRMAPTNPC1RAB9AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274705-A1 | 2-SUBSTITUTED 4-HETEROARYL-PYRIMIDINES AND THEIR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | Cyclacel Limited (GB) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001072745-A1 | 2-SUBSTITUTED 4-HETEROARYL-PYRIMIDINES AND THEIR USE IN THE TREATMETN OF PROLIFERATIVE DISORDERS | CYCLACEL LIMITED (GB) | 2001-10-04 | — | — | WO | disclosed |