SCHEMBL4385827

SCHEMBL4385827

CS(=O)(=O)OCC1CC2C=CC1C2

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 13/20 0.43
ALDH1A1 P00352 6/20 0.40
PKM P14618 3/20 0.34
TDP1 Q9NUW8 2/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
HTT P42858 1/20 0.33
TSHR P16473 2/20 0.33
ALOX15 P16050 2/20 0.32
POLB P06746 1/20 0.32
LMNA P02545 3/20 0.32
MAPT P10636 2/20 0.32
MAPK1 P28482 1/20 0.30
USP2 O75604 1/20 0.30
MMP9 P14780 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13409258 1.00 KDM4E (0.43) KDM4EALDH1A1PKMTDP1MEN1
SCHEMBL31395128 0.86 KDM4E (0.33) KDM4E
SCHEMBL31273758 0.85 KDM4E (0.39) KDM4EALDH1A1PKMTDP1MEN1
SCHEMBL15932539 0.84 KDM4E (0.39) KDM4EALDH1A1PKMTDP1TSHR
SCHEMBL31274004 0.84 KDM4E (0.39) KDM4EALDH1A1PKMTDP1TSHR
SCHEMBL14280195 0.83 KDM4E (0.42) KDM4EALDH1A1PKMTDP1MEN1
SCHEMBL3649763 0.82 KDM4E (0.38) KDM4EALDH1A1PKMTDP1MEN1
SCHEMBL3645419 0.82 KDM4E (0.38) KDM4EALDH1A1PKMTDP1MEN1
SCHEMBL145809 0.78 KDM4E (0.38) KDM4EALDH1A1PKMTDP1MEN1
SCHEMBL17934494 0.77 KDM4E (0.45) KDM4EALDH1A1PKMTDP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12054493-B2 Hepatitis B antiviral agents ENANTA PHARMACEUTICALS, INC. (US) 2024-08-06 US disclosed
US-20240018298-A1 OLEFINIC COMPOSITIONS COMPRISING HYDROCARBON RESINS ExxonMobil Product Solutions Company 2024-01-18 US disclosed
WO-2023049857-A1 HYBRID COMPOSITIONS COMPRISING OLEFINIC COMPOSITIONS AND RESIN COMPOSITIONS POLYMERIZABLE BY ADDITION OR CONDENSATION POLYMERIZATION REACTIONS MATERIA, INC. (US) 2023-03-30 WO disclosed
EP-3426245-B1 HEPATITIS B ANTIVIRAL AGENTS ENANTA PHARM INC (US) 2022-12-14 EP disclosed
US-20220127491-A1 COATING COMPOSITIONS ExxonMobil Product Solutions Company 2022-04-28 US disclosed
US-20210347935-A1 POLYMERS FOR SPECIALTY APPLICATIONS ExxonMobil Product Solutions Company 2021-11-11 US disclosed
US-20210230176-A1 HEPATITIS B ANTIVIRAL AGENTS ENANTA PHARM INC (US) 2021-07-29 US disclosed
US-10934306-B2 Hepatitis B antiviral agents ENANTA PHARMACEUTICALS, INC. (US) 2021-03-02 US disclosed
US-20200199143-A1 HEPATITIS B ANTIVIRAL AGENTS ENANTA PHARM INC (US) 2020-06-25 US disclosed
WO-2020123946-A1 COATING COMPOSITIONS MATERIA, INC. (US) 2020-06-18 WO disclosed
WO-2020072776-A1 POLYMERS FOR SPECIALTY APPLICATIONS MATERIA, INC. (US) 2020-04-09 WO disclosed
US-20190084994-A1 HEPATITIS B ANTIVIRAL AGENTS ENANTA PHARM INC (US) 2019-03-21 US disclosed
US-10179792-B2 Hepatitis B antiviral agents ENANTA PHARMACEUTICALS, INC. (US) 2019-01-15 US disclosed
US-20170253609-A1 HEPATITIS B ANTIVIRAL AGENTS ENANTA PHARMACEUTICALS, INC. 2017-09-07 US disclosed
US-8211984-B2 Ring-opening metathesis polymer, hydrogenated product thereof, method for preparing the same, and use thereof MITSUI CHEMICALS, INC. (JP) 2012-07-03 US disclosed
US-7851575-B2 Polycyclic polymers containing pendant ion conducting moieties PROMERUS LLC (US) 2010-12-14 US disclosed
US-20090215974-A1 RING-OPENING METATHESIS POLYMER, HYDROGENATED PRODUCT THEREOF, METHOD FOR PREPARING THE SAME, AND USE THEREOF MITSUI CHEMICALS INC (JP) 2009-08-27 US disclosed
EP-2045280-A1 RING-OPENING METATHESIS POLYMERS, PRODUCTS OF HYDROGENATION THEREOF, PROCESS FOR PRODUCTION OF THE SAME AND USES THEREOF Mitsui Chemicals, Inc. (JP) 2009-04-08 EP disclosed
US-20080242750-A1 Polycyclic polymers containing pendant ion conducting moieties PROMERUS LLC 2008-10-02 US disclosed
US-20080027246-A1 Process for forming perfluorinated-alkyl sulfonamide substituted norbornene-type monomers PROMERUS, LLC 2008-01-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10179792-B2 Hepatitis B antiviral agents HAVCR2, PYGL, SLC10A1 KDM4E 1148/4885ALDH1A1 3634/4885PKM 2707/4885
US-20190084994-A1 HEPATITIS B ANTIVIRAL AGENTS HAVCR2, PYGL, SLC10A1 KDM4E 1148/4885ALDH1A1 3634/4885PKM 2707/4885
US-20210230176-A1 HEPATITIS B ANTIVIRAL AGENTS HAVCR2, PYGL, SLC10A1 KDM4E 1148/4885ALDH1A1 3634/4885PKM 2707/4885
US-20080027246-A1 Process for forming perfluorinated-alkyl sulfonamide substituted norbornene-type monomers PFAS, FLNA, FLNB KDM4E 3732/4885ALDH1A1 351/4885PKM 2557/4885
US-12054493-B2 Hepatitis B antiviral agents HAVCR2, PYGL, SLC10A1 KDM4E 1148/4885ALDH1A1 3634/4885PKM 2707/4885
US-20200199143-A1 HEPATITIS B ANTIVIRAL AGENTS HAVCR2, PYGL, SLC10A1 KDM4E 1148/4885ALDH1A1 3634/4885PKM 2707/4885
US-10934306-B2 Hepatitis B antiviral agents HAVCR2, PYGL, SLC10A1 KDM4E 1148/4885ALDH1A1 3634/4885PKM 2707/4885
US-20170253609-A1 HEPATITIS B ANTIVIRAL AGENTS HAVCR2, PYGL, SLC10A1 KDM4E 1148/4885ALDH1A1 3634/4885PKM 2707/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.