Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379550 | 0.88 | ALDH1A1 (0.51) | ALDH1A1MAPTKDM4ELMNAHSD17B10 | |
| SCHEMBL4379063 | 0.85 | KDM4E (0.82) | ALDH1A1MAPTKDM4ELMNAHSD17B10 | |
| SCHEMBL4378341 | 0.79 | HTT (0.76) | ALDH1A1MAPTKDM4ELMNAHSD17B10 | |
| SCHEMBL4382063 | 0.77 | HTT (0.63) | ALDH1A1MAPTKDM4ELMNAHSD17B10 | |
| SCHEMBL27979632 | 0.73 | ALDH1A1 (0.82) | ALDH1A1MAPTKDM4ELMNAHSD17B10 | |
| SCHEMBL4375414 | 0.71 | TSHR (0.70) | ALDH1A1MAPTKDM4ELMNAHSD17B10 | |
| SCHEMBL4349596 | 0.70 | POLB (0.52) | ALDH1A1MAPTKDM4ELMNAHSD17B10 | |
| SCHEMBL14218007 | 0.70 | ALDH1A1 (0.52) | ALDH1A1MAPTKDM4ELMNAHSD17B10 | |
| SCHEMBL4381921 | 0.69 | MAPT (0.58) | ALDH1A1MAPTLMNAHSD17B10HTT | |
| SCHEMBL4378283 | 0.69 | ALDH1A1 (0.52) | ALDH1A1MAPTLMNAHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | claimed |