Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 5/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.35 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | USP10 | Q14694 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370270 | 0.82 | GRIA4 (0.44) | GRIA4GRIA2ALDH1A1MAPTHPGD | |
| SCHEMBL13863268 | 0.75 | AR (0.41) | GRIA4GRIA2ALDH1A1MAPTHPGD | |
| SCHEMBL4370222 | 0.73 | AR (0.39) | GRIA4GRIA2ALDH1A1MAPTHPGD | |
| SCHEMBL4381278 | 0.70 | AR (0.39) | ALDH1A1MAPTHPGDGAAAR | |
| SCHEMBL4374929 | 0.67 | MAPT (0.39) | ALDH1A1MAPTHPGDGAAAR | |
| SCHEMBL4386448 | 0.67 | AR (0.40) | ALDH1A1MAPTNPSR1HPGDGAA | |
| SCHEMBL6064416 | 0.65 | GRIA4 (0.54) | GRIA4GRIA2ALDH1A1HPGDGAA | |
| SCHEMBL8288401 | 0.65 | GRIA4 (0.46) | GRIA4GRIA2ALDH1A1MAPTNPSR1 | |
| SCHEMBL7468371 | 0.64 | PTGS2 (0.56) | ALDH1A1MAPTL3MBTL1HPGDGAA | |
| SCHEMBL1848834 | 0.63 | ALDH1A1 (0.60) | SLC10A6ALDH1A1MAPTNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |