Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707955 | 0.80 | NPC1 (0.46) | ALDH1A1SLC10A6NPC1MAPTRAB9A | |
| SCHEMBL11529437 | 0.78 | ALDH1A1 (0.70) | ALDH1A1SLC10A6NPC1MAPTHPGD | |
| SCHEMBL1847303 | 0.78 | ESR2 (0.58) | ALDH1A1NPC1MAPTRAB9AHPGD | |
| SCHEMBL25983222 | 0.77 | ESR2 (0.49) | ALDH1A1SLC10A6NPC1MAPTRAB9A | |
| SCHEMBL3070066 | 0.77 | ESR2 (0.45) | ALDH1A1SLC10A6NPC1MAPTRAB9A | |
| SCHEMBL31549285 | 0.76 | ALDH1A1 (0.44) | ALDH1A1SLC10A6NPC1MAPTRAB9A | |
| SCHEMBL13545969 | 0.75 | ALDH1A1 (0.49) | ALDH1A1SLC10A6NPC1MAPTRAB9A | |
| SCHEMBL11529714 | 0.74 | ALDH1A1 (0.58) | ALDH1A1SLC10A6NPC1MAPTRAB9A | |
| SCHEMBL11530053 | 0.74 | ALDH1A1 (0.55) | ALDH1A1SLC10A6NPC1MAPTRAB9A | |
| SCHEMBL28290128 | 0.73 | ALDH1A1 (0.48) | ALDH1A1SLC10A6MAPTHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884066-B | 2, 3, 5-substituted thiophene compounds as protein kinase inhibitors | 韩国科学技术研究院 | 2021-08-24 | — | — | CN | disclosed |
| EP-3418275-B1 | NOVEL 2,3,5-SUBSTITUTED THIOPHENE COMPOUND AS PROTEIN KINASE INHIBITOR | KOREA INST SCI & TECH (KR) | 2021-03-17 | — | — | EP | disclosed |
| US-10442796-B2 | 2,3,5-substituted thiophene compound as protein kinase inhibitor | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2019-10-15 | — | — | US | disclosed |
| US-20190047993-A1 | Novel 2,3,5-substituted thiophene compound as protein kinase inhibitor | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2019-02-14 | — | — | US | disclosed |
| EP-3418275-A1 | NOVEL 2,3,5-SUBSTITUTED THIOPHENE COMPOUND AS PROTEIN KINASE INHIBITOR | Korea Institute of Science and Technology (KR) | 2018-12-26 | — | — | EP | disclosed |
| CN-108884066-A | The thiophene compound that new 2,3,5- as kinases inhibitor replace | 韩国科学技术研究院 | 2018-11-23 | — | — | CN | disclosed |
| EP-2935221-B1 | QUINOLONE DERIVATIVES | CADILA HEALTHCARE LTD (IN) | 2018-02-07 | — | — | EP | disclosed |
| CN-104903295-B | Carbostyril derivative | 卡迪拉保健有限公司 | 2017-09-01 | — | — | CN | disclosed |
| WO-2017142325-A1 | NOVEL 2,3,5-SUBSTITUTED THIOPHENE COMPOUND AS PROTEIN KINASE INHIBITOR | 한국과학기술연구원 | 2017-08-24 | — | — | WO | disclosed |
| US-9394300-B2 | Quinolone derivatives | CADILA HEALTHCARE LIMITED (IN) | 2016-07-19 | — | — | US | disclosed |
| EP-1987042-A2 | NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | sanofi-aventis (FR) | 2008-11-05 | — | — | EP | disclosed |
| EP-1877401-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | Elan Pharmaceuticals Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2007093365-A2 | NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI-AVENTIS (DE) | 2007-08-23 | — | — | WO | disclosed |
| WO-2006113140-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | ELAN PHARMACEUTICALS, INC. (US) | 2006-10-26 | — | — | WO | disclosed |
| EP-1549632-A4 | NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS | DIMENSIONAL PHARM INC (US) | 2005-11-09 | — | — | EP | disclosed |
| EP-1549632-A1 | NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-07-06 | — | — | EP | disclosed |
| US-20050130997-A1 | Pyrimidinone viral polymerase inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2005-06-16 | — | — | US | disclosed |
| EP-1470113-A1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003099805-A1 | NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2003-12-04 | — | — | WO | disclosed |
| WO-2003062211-A1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10442796-B2 | 2,3,5-substituted thiophene compound as protein kinase inhibitor | CDK2, CDK2AP2, MAP3K5 | ALDH1A1 4111/4885SLC10A6 4709/4885NPC1 3240/4885 |
| US-20050130997-A1 | Pyrimidinone viral polymerase inhibitors | POLR2A, POLR1E, POLR2E | ALDH1A1 255/4885SLC10A6 3803/4885NPC1 1567/4885 |
| US-20190047993-A1 | Novel 2,3,5-substituted thiophene compound as protein kinase inhibitor | MAP3K5, MAP3K6, MAP3K9 | ALDH1A1 4145/4885SLC10A6 4725/4885NPC1 3153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.