Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.32 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.32 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4262346 | 1.00 | CCNC (0.37) | CCNCCDK8LMNAKMT2ATDP1 | |
| SCHEMBL1569020 | 1.00 | CCNC (0.37) | CCNCCDK8LMNAKMT2ATDP1 | |
| SCHEMBL4266285 | 0.91 | LMNA (0.36) | LMNAKMT2ATDP1TBXAS1BCHE | |
| SCHEMBL1569018 | 0.89 | BCHE (0.35) | CCNCCDK8LMNAKMT2ATDP1 | |
| SCHEMBL1568978 | 0.81 | KDM6B (0.34) | LMNAKMT2ATDP1TBXAS1BCHE | |
| SCHEMBL4388299 | 0.77 | CYP3A4 (0.44) | LMNAKMT2ATDP1MAPK1MEN1 | |
| SCHEMBL4390324 | 0.76 | LRRK2 (0.37) | LMNAKMT2ATDP1TBXAS1BCHE | |
| SCHEMBL2849986 | 0.74 | ALDH1A1 (0.42) | LMNAKMT2ATDP1MAPK1MEN1 | |
| SCHEMBL4394884 | 0.72 | POLB (0.47) | CCNCCDK8LMNAKMT2ATDP1 | |
| SCHEMBL4394887 | 0.72 | POLB (0.47) | CCNCCDK8LMNAKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268854-B2 | Aza-beta-carbolines and methods of using same | THE UWM RESEARCH FOUNDATION, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-20090306121-A1 | AZA-BETA-CARBOLINES AND METHODS OF USING SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306121-A1 | AZA-BETA-CARBOLINES AND METHODS OF USING SAME | CHRNA7, CHRNA2, CHRNA5 | CCNC 1812/4885CDK8 2450/4885LMNA 1655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.