Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202199 | 0.84 | KMT2A (0.40) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL2197918 | 0.78 | OPRD1 (0.44) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL3317446 | 0.76 | KMT2A (0.48) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL4396480 | 0.73 | KMT2A (0.45) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL2196605 | 0.73 | OPRL1 (0.44) | KMT2AMEN1OPRD1OPRM1OPRK1 | |
| SCHEMBL16448458 | 0.72 | OPRM1 (0.50) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL8894687 | 0.72 | KMT2A (0.44) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL5074961 | 0.71 | KMT2A (0.45) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL4677322 | 0.71 | ALDH1A1 (0.47) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL4396476 | 0.71 | KMT2A (0.46) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306038-A1 | 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity | PALAU PHARMA, S.A. (ES) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306038-A1 | 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity | HRH4, HRH2, HRH3 | KMT2A 345/4885MEN1 3414/4885SLC6A9 2919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.