Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4396480 | 0.87 | KMT2A (0.45) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL4438292 | 0.77 | OPRD1 (0.41) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL3317446 | 0.74 | KMT2A (0.48) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL5969169 | 0.74 | OPRD1 (0.35) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL23762504 | 0.73 | OPRM1 (0.46) | KMT2AMEN1SLC6A9OPRD1OPRM1 | |
| SCHEMBL71274 | 0.73 | SLC6A9 (0.43) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL14491539 | 0.73 | DPP4 (0.50) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL72670 | 0.72 | MEN1 (0.48) | KMT2AMEN1SLC6A9OPRD1ALDH1A1 | |
| SCHEMBL5069200 | 0.72 | RIPK1 (0.53) | KMT2AMEN1ALDH1A1LMNAHTT | |
| SCHEMBL1529441 | 0.72 | RIPK1 (0.53) | KMT2AMEN1ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306038-A1 | 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity | PALAU PHARMA, S.A. (ES) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306038-A1 | 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity | HRH4, HRH2, HRH3 | KMT2A 345/4885MEN1 3414/4885SLC6A9 2919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.