Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.58 |
| ▸ | RELA | Q04206 | 2/20 | 0.58 |
| ▸ | PTGES | O14684 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20654333 | 0.83 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL12277332 | 0.83 | PTGES (0.40) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL6270045 | 0.80 | PTGES (0.44) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL7483606 | 0.78 | PTGES (0.43) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL6266823 | 0.77 | PTGES (0.44) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL4389686 | 0.77 | PTGES (0.41) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL2523479 | 0.76 | TTR (0.52) | NPC1RAB9APTGESALDH1A1MEN1 | |
| SCHEMBL4391246 | 0.76 | TYK2 (0.45) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL4395916 | 0.75 | MEN1 (0.55) | NPC1RAB9ASMN1; SMN2PTGESALDH1A1 | |
| SCHEMBL3781325 | 0.73 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175407-B1 | PESTICIDAL PYRIMIDINE-DERIVATIVES | NOVARTIS AG (CH) | 2009-12-09 | — | — | EP | disclosed |
| US-6686469-B2 | TREATMENT FOR PLANT PROPAGATION MATERIAL FOR PARASITICIDES | NOVARTIS ANIMAL HEALTH US, INC. | 2004-02-03 | — | — | US | disclosed |
| US-20030004347-A1 | Pesticidal pyrimidine-derivatives | NOVARTIS ANIMAL HEALTH US, INC. | 2003-01-02 | — | — | US | disclosed |
| EP-1175407-A1 | PESTICIDAL PYRIMIDINE-DERIVATIVES | Syngenta Participations AG (CH) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066565-A1 | PESTICIDAL PYRIMIDINE-DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2000-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004347-A1 | Pesticidal pyrimidine-derivatives | CTRC, HCN1, DDT | NPC1 2584/4885RAB9A 2202/4885SMN1; SMN2 1456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.