Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378354 | 0.83 | CNR1 (0.47) | DRD2MCHR1 | |
| SCHEMBL14434976 | 0.82 | GRM5 (0.55) | IDO1GRM5CCR2DRD2MCHR1 | |
| SCHEMBL4389914 | 0.79 | DRD2 (0.41) | CCR2DRD2MCHR1 | |
| SCHEMBL14434754 | 0.76 | GRM5 (0.52) | NPC1RAB9AGRM5DRD2MCHR1 | |
| SCHEMBL4389911 | 0.74 | DRD2 (0.39) | DRD2LMNA | |
| SCHEMBL3771252 | 0.71 | ALDH1A1 (0.47) | NPC1RAB9ALMNACHRM4 | |
| SCHEMBL5425063 | 0.71 | MCHR1 (0.76) | MCHR1 | |
| SCHEMBL9256928 | 0.70 | IDO1 (0.56) | IDO1SLC2A1DRD2LMNA | |
| SCHEMBL9256924 | 0.70 | IDO1 (0.56) | IDO1SLC2A1DRD2LMNA | |
| SCHEMBL9283498 | 0.69 | IDO1 (0.44) | IDO1SLC2A1DRD2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | claimed |