Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 3/20 | 0.37 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378354 | 0.85 | CNR1 (0.47) | DRD2MAPTFFAR2MCHR1KMT2A | |
| SCHEMBL4389907 | 0.79 | HRH3 (0.44) | DRD2MCHR1CCR2 | |
| SCHEMBL894236 | 0.77 | MAPT (0.45) | DRD2DRD4DRD3MAPTDEGS1 | |
| SCHEMBL4389911 | 0.74 | DRD2 (0.39) | DRD2DRD3MAPTMEN1KMT2A | |
| SCHEMBL13267750 | 0.72 | MAPT (0.51) | DRD2MAPTDEGS1FFAR2MCHR1 | |
| SCHEMBL24581605 | 0.70 | MAPT (0.52) | DRD2MAPTDEGS1FFAR2MCHR1 | |
| SCHEMBL1324482 | 0.70 | OPRD1 (0.53) | DRD2KMT2A | |
| SCHEMBL20243406 | 0.69 | DRD2 (0.50) | DRD2MAPTDEGS1FFAR2MCHR1 | |
| SCHEMBL20565457 | 0.69 | MAPT (0.51) | DRD2MAPTDEGS1FFAR2MCHR1 | |
| SCHEMBL14218066 | 0.68 | HSD11B1 (0.55) | DRD2MAPTMCHR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | claimed |