Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | PRCP | P42785 | 2/20 | 0.35 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4389907 | 0.74 | HRH3 (0.44) | DRD2LMNA | |
| SCHEMBL4378354 | 0.74 | CNR1 (0.47) | DRD2KMT2AMAPT | |
| SCHEMBL4389914 | 0.74 | DRD2 (0.41) | DRD2MEN1KMT2ADRD3LSS | |
| SCHEMBL27809493 | 0.67 | SLC2A1 (0.42) | DRD2MEN1KMT2ALSSUSP2 | |
| SCHEMBL9408355 | 0.65 | IDO1 (0.42) | DRD2MEN1KMT2APRCPUSP2 | |
| SCHEMBL19502447 | 0.64 | HTR3A (0.44) | DRD2MEN1KMT2ALSSUSP2 | |
| SCHEMBL82136 | 0.64 | SLC18A3 (0.45) | DRD2DRD3SLC18A3 | |
| SCHEMBL11457742 | 0.64 | POLB (0.58) | MEN1KMT2ALMNAMAPT | |
| SCHEMBL175904 | 0.63 | SLC18A3 (0.57) | DRD2MEN1KMT2ASIGMAR1TP53 | |
| SCHEMBL9283502 | 0.63 | IDO1 (0.44) | DRD2MEN1KMT2ALSSUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | claimed |