SCHEMBL4390128

SCHEMBL4390128

CN(C)CCCC(NC(=O)Nc1ccc(OCc2ccccc2)cc1)c1ccc(C(=O)Nc2ccccc2NC(=O)OC(C)(C)C)cc1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 2/20 0.47
UTS2R Q9UKP6 8/20 0.47
HDAC1 Q13547 2/20 0.47
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
CASP3 P42574 1/20 0.43
TAAR1 Q96RJ0 1/20 0.43
SENP7 Q9BQF6 1/20 0.43
NOX1 Q9Y5S8 1/20 0.43
CACNA1H O95180 1/20 0.43
CACNA1B Q00975 1/20 0.43
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
MAPK1 P28482 1/20 0.42
HSD17B10 Q99714 1/20 0.42
F7 P08709 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2475578 0.92 UTS2R (0.47) UTS2RHDAC1NPC1RAB9ASMN1; SMN2
SCHEMBL2480439 0.88 UTS2R (0.47) UTS2RHDAC1
SCHEMBL2474055 0.87 UTS2R (0.47) UTS2RHDAC1NPC1RAB9ASMN1; SMN2
SCHEMBL3832774 0.85 UTS2R (0.53) UTS2R
SCHEMBL2477098 0.85 UTS2R (0.46) UTS2RHDAC1HSD17B10
SCHEMBL2476917 0.85 UTS2R (0.61) UTS2R
SCHEMBL2474768 0.85 UTS2R (0.44) UTS2RHDAC1NPC1RAB9ASMN1; SMN2
SCHEMBL2475946 0.83 UTS2R (0.46) UTS2RHDAC1
SCHEMBL2479563 0.83 UTS2R (0.44) UTS2RHDAC1
SCHEMBL2476836 0.83 UTS2R (0.48) UTS2RSMN1; SMN2CACNA1HCACNA1BMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8076332-B2 N- (2-aminophenyl) benzamide derivative having urea structure SANTEN PHARMACEUTICAL CO., LTD. (JP) 2011-12-13 US disclosed
US-20090306077-A1 NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING UREA STRUCTURE SANTEN PHARMACEUTICAL CO., LTD. (JP) 2009-12-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090306077-A1 NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING UREA STRUCTURE UACA, SLC14A1, ARG2 LTA4H 706/4885UTS2R 11/4885HDAC1 200/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.