Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | TSHR | P16473 | 4/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | CNR1 | P21554 | 1/20 | 0.66 |
| ▸ | CNR2 | P34972 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | TLR2 | O60603 | 4/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288671 | 0.89 | MAPT (0.67) | MAPTALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL2306161 | 0.87 | MAPT (0.76) | MAPTALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL20711040 | 0.86 | MAPT (0.68) | MAPTALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL8289712 | 0.86 | KDM4E (0.67) | MAPTALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL11381277 | 0.86 | ALDH1A1 (0.80) | MAPTALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL5451004 | 0.85 | MAPT (0.77) | MAPTALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL18506966 | 0.85 | KDM4E (0.78) | MAPTALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL11924525 | 0.85 | MAPT (0.73) | MAPTALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL13779376 | 0.84 | ALDH1A1 (0.81) | MAPTALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL6316126 | 0.84 | PTPN1 (0.55) | MAPTALDH1A1TSHRSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298842-A1 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor | PATO JANOS | 2009-12-03 | — | — | US | claimed |
| US-20040171603-A1 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor | VICHEM CHEMIE KFT (HU) | 2004-09-02 | — | — | US | claimed |
| US-20090298842-A1 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor | PATO JANOS | 2009-12-03 | — | — | US | disclosed |
| US-20040171603-A1 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor | VICHEM CHEMIE KFT (HU) | 2004-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298842-A1 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor | PKLR, MASTL, BPGM | MAPT 3062/4885ALDH1A1 4718/4885TSHR 3503/4885 |
| US-20040171603-A1 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor | PKLR, PKN1, PKMYT1 | MAPT 2046/4885ALDH1A1 4655/4885TSHR 3695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.