Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.40 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15931698 | 0.82 | ADRB2 (0.56) | ADRB2SMN1; SMN2MRGPRX4RAB9APOLB | |
| SCHEMBL2172285 | 0.79 | CACNA1G (0.45) | ALDH1A1MAPK1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL2173420 | 0.79 | TRPV1 (0.60) | ADRB2ALDH1A1MAPK1SMN1; SMN2RAB9A | |
| SCHEMBL15932309 | 0.77 | ADRB2 (0.48) | ADRB2ALDH1A1SMN1; SMN2HPGDMRGPRX4 | |
| SCHEMBL2173905 | 0.76 | SHMT2 (0.43) | ALDH1A1CYP1A2CYP2C19SMN1; SMN2KMT2A | |
| SCHEMBL2173918 | 0.76 | ALDH1A1 (0.42) | ALDH1A1CYP1A2CYP2C19SMN1; SMN2KMT2A | |
| SCHEMBL15932202 | 0.74 | ADRB2 (0.51) | ADRB2ALDH1A1MRGPRX4MAPTLMNA | |
| SCHEMBL15931818 | 0.71 | NPC1 (0.48) | ADRB2KMT2AMEN1MRGPRX4RAB9A | |
| SCHEMBL6402358 | 0.71 | KMT2A (0.53) | ALDH1A1SMN1; SMN2KMT2AMEN1HPGD | |
| SCHEMBL5668262 | 0.70 | GAA (0.47) | ALDH1A1MAPK1CYP1A2CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186905-A1 | ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186905-A1 | ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE | ALK, BCL3, MCL1 | ADRB2 3118/4885ALDH1A1 1466/4885MAPK1 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.