Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 5-Fluorouridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.83 |
| ▸ | TK1 | P04183 | 3/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | TK2 | O00142 | 1/20 | 0.58 |
| ▸ | PYGM | P11217 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | NT5E | P21589 | 1/20 | 0.56 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.56 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 5-Fluorouridine SCHEMBL4390962 | 1.00 | LMNA (0.83) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL15375760 | 0.91 | LMNA (0.72) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL6270910 | 0.91 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL18573179 | 0.91 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL11563300 | 0.91 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL11564431 | 0.91 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL2050487 | 0.91 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL17229 | 0.91 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL13674187 | 0.91 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL9155703 | 0.91 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010224-A2 | METHOD AND COMPOSITION FOR TREATING AND PREVENTING TUMOR METASTASIS IN VIVO | The Board of Trustees of The Leland Stanford Junior University (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007126457-A2 | METHOD AND COMPOSITION FOR TREATING AND PREVENTING TUMOR METASTASIS IN VIVO | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2007-11-08 | — | — | WO | disclosed |