Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Floxuridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.65 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.65 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.65 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.65 |
| ▸ | TK1 | P04183 | 3/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | TK2 | O00142 | 1/20 | 0.52 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.51 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 5-Fluorouridine SCHEMBL4390962 | 0.91 | LMNA (0.83) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| 5-Fluorouridine SCHEMBL4390966 | 0.91 | LMNA (0.83) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Uridine SCHEMBL2563446 | 0.89 | SLC28A1 (0.78) | LMNASMN1; SMN2SLC28A1SLC28A2SLC29A1 | |
| Idoxuridine SCHEMBL10383337 | 0.89 | TK1 (0.72) | LMNASMN1; SMN2SLC28A1SLC28A2SLC29A1 | |
| Idoxuridine SCHEMBL10383338 | 0.89 | TK1 (0.72) | LMNASMN1; SMN2SLC28A1SLC28A2SLC29A1 | |
| Doxribtimine SCHEMBL787593 | 0.89 | SLC28A1 (0.65) | LMNASMN1; SMN2SLC28A1SLC28A2SLC29A1 | |
| Cytidine SCHEMBL4468985 | 0.86 | LMNA (0.65) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Trifluridine SCHEMBL3720930 | 0.86 | LMNA (0.62) | LMNASMN1; SMN2SLC28A1SLC28A2SLC29A1 | |
| Floxuridine SCHEMBL2050487 | 0.85 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A | |
| Floxuridine SCHEMBL13674187 | 0.85 | LMNA (1.00) | LMNASMN1; SMN2TK1ALOX12ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9125926-B2 | Vicenin 2 and analogues thereof for use as an antispasmodic and/or prokinetic agent | AMINO UP CHEMICAL CO. LTD (JP) | 2015-09-08 | — | — | US | disclosed |
| US-20140322198-A1 | COMPOSITION COMPRISING VICENIN-2 HAVING A BENEFICIAL EFFECT ON NEUROLOGICAL AND/OR COGNITIVE FUNCTION | AMINO UP CHEMICAL CO., LTD. (JP) | 2014-10-30 | — | — | US | disclosed |
| US-20130303468-A1 | VICENIN 2 AND ANALOGUES THEREOF FOR USE AS AN ANTISPASMODIC AND/OR PROKINETIC AGENT | AMINO UP CHEMICAL CO., LTD. (JP) | 2013-11-14 | — | — | US | disclosed |