Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADCY1 | Q08828 | 3/20 | 0.34 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407963 | 1.00 | PKM (0.47) | PKML3MBTL1ALDH1A1KMT2AMAPT | |
| SCHEMBL408252 | 0.88 | PKM (0.43) | PKML3MBTL1ALDH1A1KMT2AMAPT | |
| SCHEMBL438512 | 0.88 | PKM (0.43) | PKML3MBTL1ALDH1A1KMT2AMAPT | |
| SCHEMBL406914 | 0.85 | KMT2A (0.39) | PKML3MBTL1ALDH1A1KMT2AMAPT | |
| SCHEMBL438289 | 0.85 | KMT2A (0.39) | PKML3MBTL1ALDH1A1KMT2AMAPT | |
| SCHEMBL408244 | 0.81 | PKM (0.46) | PKML3MBTL1ALDH1A1KMT2AMAPT | |
| SCHEMBL443006 | 0.81 | PKM (0.46) | PKML3MBTL1ALDH1A1KMT2AMAPT | |
| SCHEMBL442998 | 0.80 | PKM (0.41) | PKMKMT2ASMN1; SMN2ADCY1MEN1 | |
| SCHEMBL408407 | 0.80 | PKM (0.41) | PKMKMT2ASMN1; SMN2ADCY1MEN1 | |
| SCHEMBL439099 | 0.79 | CCR5 (0.44) | PKML3MBTL1ALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065196-A1 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065196-A1 | AMIDE COMPOUNDS | DGAT2, DGAT1, DLAT | PKM 1657/4885L3MBTL1 1197/4885ALDH1A1 272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.