Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADA | P00813 | 1/20 | 0.47 |
| ▸ | ADK | P55263 | 2/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | PYGL | P06737 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.33 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.33 |
| ▸ | GAPDH | P04406 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Aminopurine SCHEMBL5529464 | 0.82 | LMNA (0.41) | ADKPNPSMN1; SMN2LMNAPOLB | |
| Ribose (Furanose) SCHEMBL4391872 | 0.78 | ADA (0.41) | ADAADKPNPCDK1CDK4 | |
| Ribose (Furanose) SCHEMBL27484456 | 0.78 | ADA (0.41) | ADAADKPNPCDK1CDK4 | |
| Ribose (Furanose) SCHEMBL5199714 | 0.78 | ADA (0.41) | ADAADKPNPCDK1CDK4 | |
| Ribose (Furanose) SCHEMBL9702729 | 0.77 | ADA (0.42) | ADACDK1CDK4CCNB1CCND1 | |
| Adenine SCHEMBL14636444 | 0.76 | HIF1A (0.49) | ADKSMN1; SMN2POLBDPP4HIF1A | |
| Purine SCHEMBL29456595 | 0.75 | — | — | |
| Purine SCHEMBL6421376 | 0.75 | KDM4A (0.38) | SMN1; SMN2LMNAALDH1A1PI4KAPI4K2B | |
| Purine SCHEMBL3157 | 0.75 | — | — | |
| Purine SCHEMBL2120547 | 0.75 | KDM4A (0.38) | SMN1; SMN2LMNAALDH1A1PI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090299049-A1 | Bicyclic Compounds and Their Use | REPLIZYME LIMITED (GB) | 2009-12-03 | — | — | US | disclosed |
| EP-1984455-A2 | BICYCLIC COMPOUNDS AND THEIR USE | THE UNIVERSITY OF YORK (GB) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007091056-A2 | BICYCLIC COMPOUNDS AND THEIR USE | THE UNIVERSITY OF YORK (GB) | 2007-08-16 | — | — | WO | disclosed |
| EP-0305643-B1 | N-6 thienyl substituted adenosine derivatives as cardiac vasodilators | WHITBY RESEARCH INC (US) | 1994-01-05 | — | — | EP | disclosed |
| US-5043325-A | N-6 substituted adenosine derivatives as cardiac vasodilators | WHITBY RESEARCH, INC. (US) | 1991-08-27 | — | — | US | disclosed |
| EP-0180614-B1 | N-6 SUBSTITUTED ADENOSINE DERIVATIVES AS CARDIAC VASODILATORS | Whitby Research Incorporated (US) | 1990-03-07 | — | — | EP | disclosed |
| EP-0305643-A2 | N-6 thienyl substituted adenosine derivatives as cardiac vasodilators | Whitby Research Incorporated (US) | 1989-03-08 | — | — | EP | disclosed |
| EP-0300144-A2 | N-6 alkyl substituted adenosine derivatives as cardiac vasodilators | Whitby Research Incorporated (US) | 1989-01-25 | — | — | EP | disclosed |
| EP-0300145-A2 | N-6 phenyl substituted adenosine derivatives as cardiac vasodilators | Whitby Research Incorporated (US) | 1989-01-25 | — | — | EP | disclosed |
| US-4728736-A | HERPES VIRUS | SOUTHERN RESEARCH INSTITUTE (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0180614-A1 | N-6 SUBSTITUTED ADENOSINE DERIVATIVES AS CARDIAC VASODILATORS. | NELSON RES & DEV (US) | 1986-05-14 | — | — | EP | disclosed |
| WO-1985004882-A1 | N-6 SUBSTITUTED ADENOSINE DERIVATIVES AS CARDIAC VASODILATORS | NELSON RESEARCH AND DEVELOPMENT COMPANY (US) | 1985-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090299049-A1 | Bicyclic Compounds and Their Use | ERCC4, PARP1, ERCC5 | ADA 505/4885ADK 524/4885PNP 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.