Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | CPB1 | P15086 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407216 | 1.00 | NPC1 (0.52) | NPC1RAB9AHTR2ACPB1MGLL | |
| SCHEMBL3515355 | 1.00 | NPC1 (0.52) | NPC1RAB9AHTR2ACPB1MGLL | |
| SCHEMBL18428493 | 0.93 | HTR2A (0.56) | HTR2ACPB1MGLLKMT2AHSD11B1 | |
| SCHEMBL324342 | 0.93 | HTR2A (0.56) | HTR2ACPB1MGLLKMT2AHSD11B1 | |
| Bicarbonate SCHEMBL11468689 | 0.91 | HTR2A (0.54) | HTR2ACPB1MGLLKMT2AHSD11B1 | |
| SCHEMBL2980744 | 0.88 | AKR1C3 (0.56) | NPC1RAB9AHTR2ACPB1MGLL | |
| SCHEMBL2980743 | 0.88 | AKR1C3 (0.56) | NPC1RAB9AHTR2ACPB1MGLL | |
| SCHEMBL2980746 | 0.88 | AKR1C3 (0.56) | NPC1RAB9AHTR2ACPB1MGLL | |
| Acetic Acid SCHEMBL2762930 | 0.87 | HTR2A (0.51) | NPC1RAB9AHTR2ACPB1MGLL | |
| SCHEMBL26883 | 0.85 | SLC18A3 (0.51) | HTR2ACPB1MGLLKMT2AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10172378-B2 | Mono- or bicyclic carboxylic acids as off-note blockers | GIVAUDAN, SA (CH) | 2019-01-08 | — | — | US | disclosed |
| EP-2185007-B1 | MONO- OR BICYCLIC CARBOXYLIC ACIDS AS OFF-NOTE BLOCKERS | GIVAUDAN SA (CH) | 2018-05-23 | — | — | EP | disclosed |
| US-20160205978-A1 | MONO- OR BICYCLIC CARBOXYLIC ACIDS AS OFF-NOTE BLOCKERS | GIVAUDAN SA (CH) | 2016-07-21 | — | — | US | disclosed |
| US-20120065196-A1 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-15 | — | — | US | disclosed |
| US-20120065196-A1 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-15 | — | — | US | disclosed |
| US-20100311786-A1 | MONO- OR BICYCLIC CARBOXYLIC ACIDS AS OFF-NOTE BLOCKERS | GIVAUDAN SA (CH) | 2010-12-09 | — | — | US | disclosed |
| EP-2185007-A2 | MONO- OR BICYCLIC CARBOXYLIC ACIDS AS OFF-NOTE BLOCKERS | Givaudan SA (CH) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009015504-A2 | MONO- OR BICYCLIC CARBOXYLIC ACIDS AS OFF-NOTE BLOCKERS | GIVAUDAN SA (CH) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008011130-A2 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008011130-A2 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311786-A1 | MONO- OR BICYCLIC CARBOXYLIC ACIDS AS OFF-NOTE BLOCKERS | SORD, GLUL, ASNS | NPC1 2443/4885RAB9A 2876/4885HTR2A 4474/4885 |
| US-20120065196-A1 | AMIDE COMPOUNDS | DGAT2, DGAT1, DLAT | NPC1 142/4885RAB9A 1525/4885HTR2A 3673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.