Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12354936 | 0.79 | CDK5 (0.38) | PDGFRBPDGFRACDK5CDK5R1GRM1 | |
| SCHEMBL27872053 | 0.76 | MAPT (0.38) | PDGFRBPDGFRAGRM1 | |
| SCHEMBL31347172 | 0.72 | PSMD14 (0.46) | SLC40A1CYP1A2 | |
| SCHEMBL2086330 | 0.68 | HTR6 (0.61) | SLC40A1 | |
| SCHEMBL1778592 | 0.67 | L3MBTL1 (0.56) | — | |
| SCHEMBL2280415 | 0.66 | ELANE (0.42) | CDK5CDK5R1 | |
| SCHEMBL185654 | 0.66 | CCR1 (0.50) | PDGFRBPDGFRASLC40A1 | |
| SCHEMBL22533539 | 0.66 | UBE2N (0.39) | GRM1 | |
| SCHEMBL828159 | 0.63 | GAK (0.55) | NCF1 | |
| SCHEMBL4400367 | 0.63 | PDGFRB (0.72) | PDGFRBPDGFRAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056822-A1 | SUBSTITUTED PYRROLOPYRIDINES AND PYRAZOLOPYRIDINES AS KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008150914-A1 | SUBSTITUTED PYRROLOPYRIDINES AND PYRAZOLOPYRIDINES AS KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-12-11 | — | — | WO | disclosed |