Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44632 | 0.87 | LMNA (0.36) | P2RX3PIK3CA | |
| SCHEMBL43952 | 0.86 | SMPD1 (0.36) | PIK3CA | |
| SCHEMBL44473 | 0.85 | GRM5 (0.40) | SMN1; SMN2NPC1RAB9APIK3CA | |
| SCHEMBL44205 | 0.84 | SMPD1 (0.35) | P2RX3PIK3CA | |
| SCHEMBL44454 | 0.83 | CHEK2 (0.36) | P2RX3PIK3CA | |
| SCHEMBL44541 | 0.82 | PDE4B (0.41) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL44296 | 0.82 | MARK3 (0.39) | SMN1; SMN2PKM | |
| SCHEMBL44225 | 0.81 | MAPT (0.50) | ALDH1A1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL38269 | 0.80 | L3MBTL1 (0.39) | ALDH1A1SMN1; SMN2P2RX3 | |
| SCHEMBL16592880 | 0.79 | BRD4 (0.35) | SMN1; SMN2P2RX3PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |