Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.41 |
| ▸ | PDE4A | P27815 | 6/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL43952 | 0.89 | SMPD1 (0.36) | TP53MAPTS1PR1 | |
| SCHEMBL44205 | 0.87 | SMPD1 (0.35) | HPGDS1PR1 | |
| SCHEMBL44632 | 0.87 | LMNA (0.36) | PDE4BPDE4DPDE4APDE4CRXFP1 | |
| SCHEMBL44454 | 0.87 | CHEK2 (0.36) | TP53MAPTHTT | |
| SCHEMBL44296 | 0.85 | MARK3 (0.39) | SMN1; SMN2KMT2AMAPT | |
| SCHEMBL44473 | 0.85 | GRM5 (0.40) | RAB9ANPC1TYK2SMN1; SMN2TP53 | |
| SCHEMBL44556 | 0.85 | GSK3B (0.43) | TSHR | |
| SCHEMBL44956 | 0.84 | HSD17B10 (0.43) | ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL44225 | 0.83 | MAPT (0.50) | RAB9ANPC1ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL43923 | 0.82 | POLQ (0.37) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |