Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.51 |
| ▸ | NPC1 | O15118 | 9/20 | 0.51 |
| ▸ | GFER | P55789 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.48 |
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | TP53 | P04637 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6209242 | 0.86 | MAPT (0.51) | RAB9ANPC1GFERRXFP1SMN1; SMN2 | |
| SCHEMBL29974587 | 0.81 | RAB9A (0.64) | RAB9ANPC1GFERRXFP1SMN1; SMN2 | |
| SCHEMBL210184 | 0.81 | RAB9A (0.64) | RAB9ANPC1GFERRXFP1SMN1; SMN2 | |
| SCHEMBL38651946 | 0.81 | ESR2 (0.53) | SMN1; SMN2KDM4EHSD17B10PIK3CBALDH1A1 | |
| SCHEMBL9757168 | 0.81 | ESR2 (0.53) | SMN1; SMN2KDM4EHSD17B10PIK3CBALDH1A1 | |
| SCHEMBL1906793 | 0.79 | XDH (0.55) | RAB9ANPC1RXFP1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL11595567 | 0.79 | NPC1 (0.46) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL3640007 | 0.79 | MEN1 (0.56) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL3640998 | 0.79 | DAGLA (0.56) | SMN1; SMN2MAPTTP53KDM4EALDH1A1 | |
| SCHEMBL29826477 | 0.79 | XDH (0.55) | RAB9ANPC1RXFP1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605125-B2 | Anticancer agents | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-10-20 | — | — | US | claimed |
| US-20090069220-A1 | DNA-BINDING POLYAMIDE DRUG CONJUGATES | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPA (US) | 2009-03-12 | — | — | US | claimed |
| US-20050096261-A1 | Dna-binding polyamide drug conjugates | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRES ENTED BY THE SECREATARY, DEPARTMENT OF HEALTH & H (MD) | 2005-05-05 | — | — | US | claimed |
| WO-2005032594-A2 | ALKYLATORS LINKED TO POLYAMIDES AS DNA BINDING AGENTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2005-04-14 | — | — | WO | claimed |
| WO-2003072058-A2 | DNA-BINDING POLYAMIDE DRUG CONJUGATES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTATED BY THE SECRETARY, DEPARMENT OF HEALTH AND HUMAN SERVICES (US) | 2003-09-04 | — | — | WO | claimed |
| US-9758480-B2 | 1-(cycloalkyl-carbonyl)proline derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2017-09-12 | — | — | US | disclosed |
| US-20150210640-A1 | 1-(CYCLOALKYL-CARBONYL)PROLINE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2015-07-30 | — | — | US | disclosed |
| EP-2876105-A1 | 1-(CYCLOALKYL-CARBONYL)PROLINE DERIVATIVE | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2015-05-27 | — | — | EP | disclosed |
| US-7605125-B2 | Anticancer agents | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-10-20 | — | — | US | disclosed |
| US-20090069220-A1 | DNA-BINDING POLYAMIDE DRUG CONJUGATES | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPA (US) | 2009-03-12 | — | — | US | disclosed |
| US-20050096261-A1 | Dna-binding polyamide drug conjugates | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRES ENTED BY THE SECREATARY, DEPARTMENT OF HEALTH & H (MD) | 2005-05-05 | — | — | US | disclosed |
| WO-2005032594-A2 | ALKYLATORS LINKED TO POLYAMIDES AS DNA BINDING AGENTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2005-04-14 | — | — | WO | disclosed |
| WO-2003072058-A2 | DNA-BINDING POLYAMIDE DRUG CONJUGATES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTATED BY THE SECRETARY, DEPARMENT OF HEALTH AND HUMAN SERVICES (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096261-A1 | Dna-binding polyamide drug conjugates | ZYX, BMX, CDYL | RAB9A 4445/4885NPC1 1776/4885GFER 2780/4885 |
| US-20090069220-A1 | DNA-BINDING POLYAMIDE DRUG CONJUGATES | TOP2B, ZYX, TOP2A | RAB9A 3139/4885NPC1 2966/4885GFER 2527/4885 |
| US-20150210640-A1 | 1-(CYCLOALKYL-CARBONYL)PROLINE DERIVATIVE | RB1, F2, SFPQ | RAB9A 812/4885NPC1 4753/4885GFER 3834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.