Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3190220 | 0.85 | ALOX15 (0.61) | SMN1; SMN2GAAGPR34PTGDR2FFAR1 | |
| SCHEMBL16661979 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAGPR34GSK3BSMPD1 | |
| SCHEMBL10967825 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAGPR34GSK3BSMPD1 | |
| SCHEMBL10967799 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2GAAGPR34GSK3BSMPD1 | |
| SCHEMBL4362709 | 0.82 | LMNA (0.56) | GAA | |
| SCHEMBL4841249 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2GAAGPR34 | |
| SCHEMBL15647515 | 0.81 | MAPT (0.53) | GAA | |
| SCHEMBL6320208 | 0.80 | KCNH2 (0.48) | SMN1; SMN2PTGDR2 | |
| SCHEMBL10289328 | 0.79 | PPARA (0.55) | SMN1; SMN2GAA | |
| SCHEMBL17460125 | 0.78 | MGLL (0.51) | SMN1; SMN2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959951-B1 | HETEROARYL SUBSTITUTED PIPERIDINE DERIVATIVES AS L-CPT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-12-23 | — | — | EP | disclosed |