Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phendimetrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A3 known ✓ | Q01959 | 4/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phendimetrazine SCHEMBL4381184 | 0.87 | HTR1A (0.75) | HTR1ASLC6A2SLC6A3ADRA1AHTR2B | |
| Phendimetrazine SCHEMBL344020 | 0.82 | HTR1A (1.00) | HTR1ASLC6A2SLC6A3ADRA1AHTR2B | |
| Phendimetrazine SCHEMBL598950 | 0.82 | HTR1A (1.00) | HTR1ASLC6A2SLC6A3ADRA1AHTR2B | |
| Phendimetrazine SCHEMBL49481 | 0.82 | HTR1A (1.00) | HTR1ASLC6A2SLC6A3ADRA1AHTR2B | |
| Phendimetrazine SCHEMBL15064942 | 0.82 | HTR1A (1.00) | HTR1ASLC6A2SLC6A3ADRA1AHTR2B | |
| Phendimetrazine SCHEMBL678276 | 0.81 | HTR1A (0.96) | HTR1ASLC6A2SLC6A3ADRA1AHTR2B | |
| Phenmetrazine SCHEMBL4385399 | 0.80 | SLC6A2 (0.65) | HTR1ASLC6A2SLC6A3ADRA1AHTR2B | |
| Phendimetrazine SCHEMBL678073 | 0.79 | HTR1A (0.93) | HTR1ASLC6A2SLC6A3ADRA1AHTR2B | |
| Phendimetrazine SCHEMBL2325477 | 0.79 | HTR1A (0.75) | HTR1ASLC6A2SLC6A3ADRA1AHTR2B | |
| Phendimetrazine SCHEMBL160375 | 0.76 | HTR1A (0.75) | HTR1ASLC6A2SLC6A3ADRA1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121029-A2 | PRODRUGS AND METHODS OF MAKING AND USING THE SAME | Neurogesx, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20080318905-A1 | Prodrugs and methods of making and using the same | NEUROGESX, INC. | 2008-12-25 | — | — | US | disclosed |
| WO-2008070149-A2 | PRODRUGS AND METHODS OF MAKING AND USING THE SAME | NEUROGESX, INC. (US) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318905-A1 | Prodrugs and methods of making and using the same | NAPEPLD, CES2, MTAP | SLC6A2 106/4885SLC6A3 153/4885HTR1A 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.