Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.34 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.34 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.34 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 6/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4396942 | 0.92 | PARP1 (0.34) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1PARP1 | |
| SCHEMBL4405858 | 0.92 | PARP1 (0.34) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1PARP1 | |
| SCHEMBL914354 | 0.89 | KMT2A (0.40) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1PARP1 | |
| SCHEMBL4396432 | 0.89 | HTR1A (0.36) | PARP1SLC6A4HTR1ALMNAKMT2A | |
| SCHEMBL4551076 | 0.87 | HTR1A (0.33) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1PARP1 | |
| SCHEMBL4403759 | 0.85 | HTR1A (0.37) | PARP1SLC6A4DRD2HTR2BHTR1A | |
| SCHEMBL4397029 | 0.84 | DRD2 (0.33) | SLC6A4DRD2HTR1AADRB3 | |
| SCHEMBL4398650 | 0.83 | GUCY1B2 (0.35) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1PARP1 | |
| SCHEMBL4400739 | 0.81 | GUCY1B2 (0.37) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1PARP1 | |
| SCHEMBL913924 | 0.81 | KMT2A (0.42) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |