Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4403759 | 0.97 | HTR1A (0.37) | HTR1ASLC6A4PARP1LMNATLR9 | |
| SCHEMBL4396942 | 0.91 | PARP1 (0.34) | HTR1ASLC6A4PARP1TLR9TLR8 | |
| SCHEMBL4405858 | 0.91 | PARP1 (0.34) | HTR1ASLC6A4PARP1TLR9TLR8 | |
| SCHEMBL4403441 | 0.90 | HTR1A (0.40) | HTR1ASLC6A4PARP1LMNATLR9 | |
| SCHEMBL4405338 | 0.89 | TERT (0.36) | HTR1ASLC6A4PARP1LMNAMTNR1A | |
| SCHEMBL4396601 | 0.89 | GUCY1B2 (0.34) | HTR1ASLC6A4PARP1LMNAMTNR1A | |
| SCHEMBL914493 | 0.88 | KMT2A (0.43) | HTR1ASLC6A4PARP1TLR9TLR8 | |
| SCHEMBL4412712 | 0.87 | LMNA (0.36) | HTR1ASLC6A4PARP1LMNA | |
| SCHEMBL4400766 | 0.85 | TERT (0.37) | HTR1ASLC6A4PARP1 | |
| SCHEMBL4411341 | 0.85 | HTR1A (0.34) | HTR1ASLC6A4PARP1TLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |