Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.53 |
| ▸ | CDK2 | P24941 | 5/20 | 0.53 |
| ▸ | SRC | P12931 | 5/20 | 0.53 |
| ▸ | ZAP70 | P43403 | 5/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4390469 | 0.88 | ALDH1A1 (0.62) | SYKCDK2SRCZAP70PIK3CA | |
| SCHEMBL5034190 | 0.83 | SYK (0.76) | SYKCDK2SRCZAP70MAPT | |
| SCHEMBL4384443 | 0.77 | SYK (0.70) | SYKCDK2SRCZAP70PIK3CA | |
| SCHEMBL4386062 | 0.77 | CYP1A1 (0.66) | CDK2PIK3CAPIK3CBPIK3CGIKBKB | |
| SCHEMBL12050106 | 0.76 | MAPT (0.74) | MAPTALDH1A1GAANPC1NFKB1 | |
| Fenclozic Acid SCHEMBL27104 | 0.74 | LMNA (0.73) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL13924481 | 0.73 | SYK (0.77) | SYKCDK2SRCZAP70PIK3CA | |
| SCHEMBL4391861 | 0.73 | CDK2 (0.50) | SYKCDK2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL4385796 | 0.72 | CDK2 (0.58) | SYKCDK2SRCZAP70PIK3CA | |
| SCHEMBL14216224 | 0.72 | SYK (0.70) | SYKCDK2SRCZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751146-B1 | PYRIDINYL- OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | CYCLACEL LTD (GB) | 2009-12-02 | — | — | EP | claimed |