Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | SYK | P43405 | 7/20 | 0.53 |
| ▸ | CDK2 | P24941 | 6/20 | 0.53 |
| ▸ | SRC | P12931 | 5/20 | 0.53 |
| ▸ | ZAP70 | P43403 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4396898 | 0.88 | SYK (0.53) | ALDH1A1SYKCDK2SRCZAP70 | |
| SCHEMBL4384443 | 0.77 | SYK (0.70) | ALDH1A1SYKCDK2SRCZAP70 | |
| SCHEMBL27344271 | 0.77 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5034190 | 0.74 | SYK (0.76) | SYKCDK2SRCZAP70MAPT | |
| SCHEMBL4386062 | 0.72 | CYP1A1 (0.66) | CDK2MAPTPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14021174 | 0.71 | PIK3CA (0.60) | ALDH1A1CDK2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13924481 | 0.71 | SYK (0.77) | SYKCDK2SRCZAP70PIK3CA | |
| SCHEMBL4387241 | 0.70 | LMNA (0.55) | ALDH1A1SYKCDK2ZAP70MAPT | |
| SCHEMBL4072590 | 0.70 | PIK3CA (0.70) | SYKCDK2SRCPIK3CAPIK3CB | |
| SCHEMBL5036868 | 0.70 | SYK (0.76) | SYKCDK2SRCZAP70JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318954-A1 | Compounds | CYCLACEL LIMITED (GB) | 2008-12-25 | — | — | US | claimed |
| EP-1751146-A2 | PYRIDINYL- OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | Cyclacel Limited (GB) | 2007-02-14 | — | — | EP | claimed |
| WO-2005075468-A2 | PYRIDINYL - OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | CYCLACEL LIMITED (GB) | 2005-08-18 | — | — | WO | claimed |
| EP-1751146-B1 | PYRIDINYL- OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | CYCLACEL LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| US-20080318954-A1 | Compounds | CYCLACEL LIMITED (GB) | 2008-12-25 | — | — | US | disclosed |
| US-20080318954-A1 | Compounds | CYCLACEL LIMITED (GB) | 2008-12-25 | — | — | US | disclosed |
| US-20080318954-A1 | Compounds | CYCLACEL LIMITED (GB) | 2008-12-25 | — | — | US | disclosed |
| EP-1751146-A2 | PYRIDINYL- OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | Cyclacel Limited (GB) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005075468-A2 | PYRIDINYL - OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | CYCLACEL LIMITED (GB) | 2005-08-18 | — | — | WO | disclosed |
| WO-2005075468-A2 | PYRIDINYL - OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | CYCLACEL LIMITED (GB) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318954-A1 | Compounds | CBR3, NR3C2, NR5A1 | ALDH1A1 1920/4885SYK 3919/4885CDK2 1186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.