Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783063 | 0.75 | MMP2 (0.38) | CFTRGOPCCHRM2CHRM4SMN1; SMN2 | |
| SCHEMBL25366741 | 0.69 | LMNA (0.36) | CFTRGOPCLMNACYP2C9MAPT | |
| SCHEMBL25366744 | 0.69 | LMNA (0.36) | CFTRGOPCLMNACYP2C9MAPT | |
| SCHEMBL3530372 | 0.64 | ALDH1A1 (0.36) | LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL7635908 | 0.64 | CFTR (0.56) | CFTRGOPCLMNACYP2C9CHRM2 | |
| SCHEMBL3641710 | 0.64 | BACE1 (0.33) | CFTRGOPCLMNACYP2C9SMN1; SMN2 | |
| SCHEMBL9846603 | 0.63 | MMP2 (0.34) | CFTRGOPCCYP2C9CHRM2CHRM4 | |
| SCHEMBL11469864 | 0.62 | CFTR (0.39) | CFTRGOPCLMNACYP2C9CHRM2 | |
| SCHEMBL9304904 | 0.62 | CFTR (0.54) | CFTRGOPCLMNACYP2C9CHRM2 | |
| SCHEMBL11881667 | 0.61 | MMP2 (0.41) | CFTRGOPCCYP2C9CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306134-A1 | Muscarinic receptor antagonists | THERAVANCE BIOPHARMA R&D IP, LLC | 2009-12-10 | — | — | US | disclosed |
| US-7456203-B2 | Muscarinic receptor antagonists | THERAVANCE, INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20040110229-A1 | Muscarinic receptor antagonists | PNC BANK, NATIONAL ASSOCIATION | 2004-06-10 | — | — | US | disclosed |
| US-6693202-B1 | MULTIBINDING LIGANDS CONTAINING SUCH AS AMINE, AMIDE, ESTER, HYDROXYL, CARBAMATE, UREA AND/OR IMINO FUNCTIONALITY | THERAVANCE, INC. | 2004-02-17 | — | — | US | disclosed |
| EP-1086066-A4 | MUSCARINIC RECEPTOR ANTAGONISTS | ADVANCED MEDICINE INC (US) | 2001-08-08 | — | — | EP | disclosed |
| EP-1086066-A1 | MUSCARINIC RECEPTOR ANTAGONISTS | Advanced Medicine, Inc. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064043-A9 | MUSCARINIC RECEPTOR ANTAGONISTS | ADVANCED MEDICINE INC (US) | 2000-03-02 | — | — | WO | disclosed |
| WO-1999064043-A1 | MUSCARINIC RECEPTOR ANTAGONISTS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110229-A1 | Muscarinic receptor antagonists | CHRM3, CHRM5, CHRM2 | CFTR 221/4885GOPC 1413/4885LMNA 4772/4885 |
| US-20090306134-A1 | Muscarinic receptor antagonists | CHRM3, CHRM5, CHRM2 | CFTR 221/4885GOPC 1413/4885LMNA 4772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.