Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.37 |
| ▸ | OTC | P00480 | 1/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 3/20 | 0.32 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL4411115 | 0.96 | PRCP (0.34) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL11905364 | 0.95 | PRCP (0.40) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL28469088 | 0.94 | PRCP (0.35) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL29206209 | 0.94 | PRCP (0.35) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL4278540 | 0.93 | PRCP (0.35) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL28868287 | 0.93 | GSR (0.38) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL29157307 | 0.93 | PRCP (0.35) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL1473089 | 0.93 | GSR (0.38) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL4398586 | 0.93 | PRCP (0.36) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL25168271 | 0.92 | PRCP (0.36) | PRCPOTCDDAH1NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6962904-B1 | Elastin peptide analogs and uses thereof | CONNECTIVE TISSUE IMAGINEERING (US) | 2005-11-08 | — | — | US | disclosed |
| US-20050054578-A1 | Elastin peptide analogs and uses thereof | SANDBERG LAWRENCE B (US) | 2005-03-10 | — | — | US | disclosed |
| US-6809075-B1 | Elastin peptide analogs and uses of same incombination with skin enhancing agents | CONNECTIVE TISSUE IMAGINEERING LLC | 2004-10-26 | — | — | US | disclosed |
| US-6794362-B1 | TOPICAL COSMETIC APPLIED AS EMULSION, LOTION, SPRAY, POWDER, OINTMENT, CREAM, INCREASES SKIN'S TURGOR | CONNECTIVE TISSUE IMAGINEERING LLC | 2004-09-21 | — | — | US | disclosed |
| US-6506731-B1 | Peptide or peptide-like compound(s) of the present invention appear to aid the elasticity and/or turgor of the skin | CONNECTIVE TISSUE IMAGINEERING LLC | 2003-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054578-A1 | Elastin peptide analogs and uses thereof | ELANE, CUTA, ENPEP | PRCP 347/4885OTC 1356/4885DDAH1 2138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.