Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 10/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405967 | 0.88 | AOC3 (0.38) | AOC3TPSAB1POLBTP53F10 | |
| Hydrochloric Acid SCHEMBL4404473 | 0.82 | TPSAB1 (0.54) | TPSAB1CYP3A4CYP2D6KCNH2F10 | |
| SCHEMBL4399213 | 0.82 | TPSAB1 (0.41) | TPSAB1 | |
| SCHEMBL4404682 | 0.78 | TPSAB1 (0.42) | TPSAB1 | |
| SCHEMBL4406792 | 0.78 | JAK2 (0.41) | TPSAB1POLB | |
| SCHEMBL4405554 | 0.77 | POLB (0.39) | POLBCYP2C19 | |
| SCHEMBL7026398 | 0.76 | TPSAB1 (0.39) | TPSAB1CYP2C19 | |
| Hydrochloric Acid SCHEMBL4405348 | 0.76 | TPSAB1 (0.38) | TPSAB1CYP2C19 | |
| SCHEMBL7025355 | 0.76 | TPSAB1 (0.44) | TPSAB1CYP3A4CYP2D6KCNH2F10 | |
| Hydrochloric Acid SCHEMBL6491184 | 0.75 | TPSAB1 (0.43) | AOC3TPSAB1CYP3A4CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296972-B1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | AVENTIS PHARMA INC (US) | 2009-12-23 | — | — | EP | disclosed |
| US-6977263-B2 | Chemical compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2005-12-20 | — | — | US | disclosed |
| US-20050228018-A1 | Chemical compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2005-10-13 | — | — | US | disclosed |
| US-20030187020-A1 | Chemical compounds | AVENTISUB LLC | 2003-10-02 | — | — | US | disclosed |
| EP-1296972-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001090101-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228018-A1 | Chemical compounds | CMA1, TPSB2, TPSG1 | AOC3 454/4885TPSAB1 4/4885POLB 3914/4885 |
| US-20030187020-A1 | Chemical compounds | CMA1, TPSB2, TPSG1 | AOC3 454/4885TPSAB1 4/4885POLB 3914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.