⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4401595 | 0.84 | ALDH1A1 (0.31) | — | |
| SCHEMBL6376109 | 0.74 | L3MBTL1 (0.33) | — | |
| SCHEMBL4399341 | 0.74 | — | — | |
| SCHEMBL7360452 | 0.73 | FAAH (0.32) | — | |
| SCHEMBL2369153 | 0.73 | FAAH (0.43) | — | |
| SCHEMBL28412788 | 0.72 | LMNA (0.44) | — | |
| SCHEMBL16584845 | 0.72 | LMNA (0.44) | — | |
| SCHEMBL24759068 | 0.71 | FAAH (0.35) | — | |
| SCHEMBL16689921 | 0.71 | FAAH (0.35) | — | |
| SCHEMBL753366 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090305382-A1 | ALKOXY INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-12-10 | — | — | US | disclosed |
| EP-1926725-A1 | ALKOXY INDOLINONE BASED PROTEIN KINASE INHIBITORS | The Scripps Research Institute (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007038251-A1 | ALKOXY INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-04-05 | — | — | WO | disclosed |