SCHEMBL4400486

SCHEMBL4400486

C1=CC2CC1CC2COc1ccccc1-c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.43
MAPK1 P28482 1/20 0.43
RAB9A P51151 1/20 0.43
KDM4E B2RXH2 4/20 0.43
TSHR P16473 1/20 0.43
FFAR4 Q5NUL3 1/20 0.42
HTR7 P34969 1/20 0.41
TDP1 Q9NUW8 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
ADRB2 P07550 3/20 0.39
LMNA P02545 4/20 0.39
ADRA1D P25100 2/20 0.39
ADRA1A P35348 2/20 0.39
ADRA1B P35368 2/20 0.39
HTT P42858 1/20 0.39
MAOA P21397 1/20 0.39
MAOB P27338 1/20 0.39
NISCH Q9Y2I1 1/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14449088 1.00 TP53 (0.43) TP53MAPK1RAB9AKDM4ETSHR
SCHEMBL20375119 0.86 TP53 (0.48) TP53MAPK1RAB9AKDM4ETSHR
SCHEMBL18560859 0.86 TP53 (0.48) TP53MAPK1RAB9AKDM4ETSHR
SCHEMBL29419414 0.86 TP53 (0.48) TP53MAPK1RAB9AKDM4ETSHR
SCHEMBL24834544 0.81 FFAR4 (0.51) MAPK1KDM4ETSHRFFAR4TDP1
SCHEMBL13005234 0.81 FFAR4 (0.51) MAPK1KDM4ETSHRFFAR4TDP1
SCHEMBL4403001 0.80 KDM4E (0.50) MAPK1KDM4ETSHRFFAR4TDP1
SCHEMBL4403004 0.78 HTR1B (0.43) KDM4ETSHRTDP1MEN1KMT2A
SCHEMBL201988 0.76 CHRNB2 (0.56) KDM4EFFAR4TDP1ALDH1A1
SCHEMBL18587062 0.76 KDM4E (0.44) KDM4ETSHRHTR7TDP1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120077076-A Composition and method for producing the same 默克专利有限公司 2025-05-30 CN claimed
US-11667731-B2 Stabilized UV active organopalladium compounds as vinyl addition catalysts PROMERUS, LLC (US) 2023-06-06 US claimed
US-20230038665-A1 STABILIZED UV ACTIVE ORGANOPALLADIUM COMPOUNDS AS VINYL ADDITON CATALYSTS PROMERUS, LLC (US) 2023-02-09 US claimed
CN-120077076-A Composition and method for producing the same 默克专利有限公司 2025-05-30 CN disclosed
US-12037431-B2 Stable mass polymerizable polycycloolefin compositions as 3D printing materials and a method of fabrication thereof PROMERUS, LLC (US) 2024-07-16 US disclosed
US-12037431-B2 Stable mass polymerizable polycycloolefin compositions as 3D printing materials and a method of fabrication thereof PROMERUS, LLC (US) 2024-07-16 US disclosed
CN-118317992-A Dual UV blocker comprising a shelf-life stable photoactive bulk polymerized polycycloolefin composition as an optical material 普罗米鲁斯有限责任公司 2024-07-09 CN disclosed
WO-2024083874-A1 COMPOSITION MERCK PATENT GMBH (DE) 2024-04-25 WO disclosed
US-11897991-B2 UV active derivatives of Pd(AcAc)2 catalyzed polycycloolefin compositions as optical materials PROMERUS, LLC (US) 2024-02-13 US disclosed
EP-4288479-A1 LONG SHELF LIFE STABLE PHOTOACTIVE MASS POLYMERIZABLE POLYCYCLOOLEFIN COMPOSITIONS AS OPTICAL MATERIALS Promerus, LLC (US) 2023-12-13 EP disclosed
US-11795285-B2 Dual UV blockers containing stable photoactive mass polymerizable polycycloolefin compositions as optical materials PROMERUS, LLC (US) 2023-10-24 US disclosed
US-8178604-B2 Solid materials obtainable by ring-opening metathesis polymerization 3M INNOVATIVE PROPERTIES COMPANY (US) 2012-05-15 US disclosed
EP-1815838-B1 Solid materials obtainable by the ring-opening methathesis polymerization 3M INNOVATIVE PROPERTIES CO (US) 2010-09-08 EP disclosed
US-20100036015-A1 COMPOSITIONS CURABLE BY RING OPENING METATHESIS POLYMERIZATION AT LOW TEMPERATURES AND THEIR APPLICATION IN THE DENTAL FIELD 3M INNOVATIVE PROPERTIES COMPANY 2010-02-11 US disclosed
US-20100036015-A1 COMPOSITIONS CURABLE BY RING OPENING METATHESIS POLYMERIZATION AT LOW TEMPERATURES AND THEIR APPLICATION IN THE DENTAL FIELD 3M INNOVATIVE PROPERTIES COMPANY 2010-02-11 US disclosed
US-20090088494-A1 SOLID MATERIALS OBTAINABLE BY RING-OPENING METATHESIS POLYMERIZATION 3M INNOVATIVE PROPERTIES COMPANY 2009-04-02 US disclosed
US-20090088494-A1 SOLID MATERIALS OBTAINABLE BY RING-OPENING METATHESIS POLYMERIZATION 3M INNOVATIVE PROPERTIES COMPANY 2009-04-02 US disclosed
EP-1942125-A1 Compositions curable by ring opening metathesis polymerarization at low temperatures and their application in the dental field 3M Innovative Properties Company (US) 2008-07-09 EP disclosed
WO-2008077001-A1 COMPOSITIONS CURABLE BY RING OPENING METATHESIS POLYMERIZATION AT LOW TEMPERATURES AND THEIR APPLICATION IN THE DENTAL FIELD 3M INNOVATIVE PROPERTIES COMPANY (US) 2008-06-26 WO disclosed
WO-2007089801-A1 SOLID MATERIALS OBTAINABLE BY RING-OPENING METATHESIS POLYMERIZATION 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-08-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100036015-A1 COMPOSITIONS CURABLE BY RING OPENING METATHESIS POLYMERIZATION AT LOW TEMPERATURES AND THEIR APPLICATION IN THE DENTAL FIELD DNMT3B, HMBS, MMAB TP53 4156/4885MAPK1 4405/4885RAB9A 1469/4885
US-12037431-B2 Stable mass polymerizable polycycloolefin compositions as 3D printing materials and a method of fabrication thereof RRP15, PPOX, NONO TP53 2803/4885MAPK1 2955/4885RAB9A 2324/4885
US-20090088494-A1 SOLID MATERIALS OBTAINABLE BY RING-OPENING METATHESIS POLYMERIZATION MMAB, DNMT3B, RHEB TP53 3149/4885MAPK1 4200/4885RAB9A 926/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.