Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 6/20 | 0.91 |
| ▸ | CASP3 | P42574 | 6/20 | 0.91 |
| ▸ | CASP9 | P55211 | 6/20 | 0.91 |
| ▸ | CYCS | P99999 | 6/20 | 0.91 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4391634 | 0.96 | APAF1 (0.86) | APAF1CASP3CASP9CYCSACHE | |
| SCHEMBL4388693 | 0.95 | APAF1 (1.00) | APAF1CASP3CASP9CYCSACHE | |
| SCHEMBL4396565 | 0.94 | APAF1 (0.83) | APAF1CASP3CASP9CYCSACHE | |
| SCHEMBL4395653 | 0.91 | APAF1 (0.90) | APAF1CASP3CASP9CYCSACHE | |
| SCHEMBL4398368 | 0.91 | APAF1 (0.87) | APAF1CASP3CASP9CYCSACHE | |
| SCHEMBL4397286 | 0.90 | APAF1 (0.90) | APAF1CASP3CASP9CYCSACHE | |
| SCHEMBL4541497 | 0.89 | APAF1 (0.86) | APAF1CASP3CASP9CYCSACHE | |
| SCHEMBL4395693 | 0.86 | APAF1 (0.79) | APAF1CASP3CASP9CYCSACHE | |
| SCHEMBL3697511 | 0.85 | APAF1 (0.91) | APAF1CASP3CASP9CYCSACHE | |
| SCHEMBL4391987 | 0.85 | APAF1 (0.77) | APAF1CASP3CASP9CYCSACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963357-B1 | COMPOUNDS FOR THE INHIBITION OF APOPTOSIS | SALVAT LAB SA (ES) | 2009-12-09 | — | — | EP | disclosed |