SCHEMBL4541497 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	APAF1	O14727	6/20	0.86

▸	CASP3	P42574	6/20	0.86

▸	CASP9	P55211	6/20	0.86

▸	CYCS	P99999	6/20	0.86

▸	ACHE	P22303	2/20	0.40

▸	CCR5	P51681	1/20	0.37

▸	CTSD	P07339	1/20	0.34

▸	TACR1	P25103	1/20	0.33

▸	FDFT1	P37268	1/20	0.33

▸	P2RX7	Q99572	1/20	0.33

▸	BCHE	P06276	1/20	0.33

▸	MC4R	P32245	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4388693	0.93	APAF1 (1.00)	APAF1CASP3CASP9CYCSACHE
SCHEMBL4396565	0.90	APAF1 (0.83)	APAF1CASP3CASP9CYCSACHE
SCHEMBL4395653	0.90	APAF1 (0.90)	APAF1CASP3CASP9CYCSACHE
SCHEMBL4401180	0.89	APAF1 (0.91)	APAF1CASP3CASP9CYCSACHE
SCHEMBL4398368	0.88	APAF1 (0.87)	APAF1CASP3CASP9CYCSACHE
SCHEMBL4397286	0.88	APAF1 (0.90)	APAF1CASP3CASP9CYCSACHE
SCHEMBL4391634	0.88	APAF1 (0.86)	APAF1CASP3CASP9CYCSACHE
SCHEMBL4391987	0.82	APAF1 (0.77)	APAF1CASP3CASP9CYCSACHE
SCHEMBL4395693	0.82	APAF1 (0.79)	APAF1CASP3CASP9CYCSACHE
SCHEMBL4394053	0.81	APAF1 (0.77)	APAF1CASP3CASP9CYCSACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1963357-B1	COMPOUNDS FOR THE INHIBITION OF APOPTOSIS	SALVAT LAB SA (ES)	2009-12-09	—	—	EP	disclosed