Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 9/20 | 0.38 |
| ▸ | MMP3 | P08254 | 9/20 | 0.38 |
| ▸ | MMP7 | P09237 | 9/20 | 0.38 |
| ▸ | MMP9 | P14780 | 9/20 | 0.38 |
| ▸ | MMP13 | P45452 | 8/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4403922 | 0.92 | KMT2A (0.50) | ALDH1A1KMT2APOLBMMP1MMP3 | |
| SCHEMBL4409172 | 0.87 | ALDH1A1 (0.46) | ALDH1A1KMT2AMMP1MMP3MMP7 | |
| SCHEMBL4403109 | 0.86 | ALDH1A1 (0.49) | ALDH1A1KMT2AMMP1MMP3MMP7 | |
| SCHEMBL4402272 | 0.85 | ALDH1A1 (0.48) | ALDH1A1KMT2AMMP1MMP3MMP7 | |
| SCHEMBL4403936 | 0.85 | ALDH1A1 (0.44) | ALDH1A1KMT2AMMP1MMP3MMP7 | |
| SCHEMBL4409179 | 0.83 | ALDH1A1 (0.46) | ALDH1A1KMT2AMMP1MMP3MMP7 | |
| SCHEMBL4403091 | 0.83 | ALDH1A1 (0.46) | ALDH1A1KMT2AMMP1MMP3MMP7 | |
| SCHEMBL4402247 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KMT2AMMP1MMP3MMP7 | |
| SCHEMBL4403933 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KMT2AMMP1MMP3MMP7 | |
| SCHEMBL4402268 | 0.71 | MMP1 (0.43) | ALDH1A1KMT2AMMP1MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120107273-A1 | NEW PIPERAZINE COMPOUND AND USE THEREOF AS A HCV POLYMERASE INHIBITOR | JAPAN TOBACCO INC. (JP) | 2012-05-03 | — | — | US | disclosed |
| US-8017612-B2 | therapeutic agent for hepatitis C; R)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazine-1,3-dicarboxylic acid 3-(4-isopropyl-benzylamide) 1-pyridin-4-ylamide; enzyme inhibitors | JAPAN TOBACCO INC. (JP) | 2011-09-13 | — | — | US | disclosed |
| US-20080081818-A1 | therapeutic agent for hepatitis C; R)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazine-1,3-dicarboxylic acid 3-(4-isopropyl-benzylamide) 1-pyridin-4-ylamide; enzyme inhibitors | JAPAN TOBACCO INC. (JP) | 2008-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081818-A1 | therapeutic agent for hepatitis C; R)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazine-1,3-dicarboxylic acid 3-(4-isopropyl-benzylamide) 1-pyridin-4-ylamide; enzyme inhibitors | HAVCR2, AADAC, DNPEP | ALDH1A1 96/4885KMT2A 779/4885POLB 573/4885 |
| US-20120107273-A1 | NEW PIPERAZINE COMPOUND AND USE THEREOF AS A HCV POLYMERASE INHIBITOR | POLR1C, POLR2E, POLR2H | ALDH1A1 557/4885KMT2A 1343/4885POLB 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.