Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31545085 | 0.76 | LMNA (0.70) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL5698477 | 0.74 | LMNA (0.42) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL4440899 | 0.74 | LMNA (0.42) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL13782375 | 0.74 | LMNA (0.42) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL9706627 | 0.74 | LMNA (0.47) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL6435607 | 0.74 | LMNA (0.42) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL13726989 | 0.74 | LMNA (0.42) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL13985486 | 0.72 | LMNA (0.41) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL17002563 | 0.71 | DRD3 (0.47) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL7792048 | 0.71 | LMNA (0.40) | LMNACES2MEN1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109611-B1 | 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MAN CO LTD (JP) | 2015-01-07 | — | — | EP | disclosed |
| US-8178552-B2 | 7-Azaindole derivatives and their use in the inhibition of c-Jun N-terminal kinase | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-05-15 | — | — | US | disclosed |
| US-8178552-B2 | 7-Azaindole derivatives and their use in the inhibition of c-Jun N-terminal kinase | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-05-15 | — | — | US | disclosed |
| WO-2008095944-A1 | 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO. LTD. (JP) | 2008-08-14 | — | — | WO | disclosed |