Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 6/20 | 0.63 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.63 |
| ▸ | CA1 | P00915 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA4 | P22748 | 1/20 | 0.59 |
| ▸ | CA6 | P23280 | 1/20 | 0.59 |
| ▸ | CA5A | P35218 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.59 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 10/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31519036 | 1.00 | HSD17B1 (0.63) | HSD17B1HSD17B2CA1CA2CA12 | |
| Phosphoric Acid SCHEMBL8381672 | 0.94 | HSD17B1 (0.57) | HSD17B1HSD17B2CA1CA2CA12 | |
| SCHEMBL4402092 | 0.86 | CA2 (0.59) | HSD17B1HSD17B2CA1CA2CA12 | |
| SCHEMBL4352378 | 0.86 | HSD17B1 (0.67) | HSD17B1HSD17B2CA1CA2CA12 | |
| Phosphoric Acid SCHEMBL8773256 | 0.83 | MAOB (0.48) | HSD17B1HSD17B2MAOBCYP1A2CYP3A4 | |
| SCHEMBL9050628 | 0.83 | HSD17B1 (0.63) | HSD17B1HSD17B2CA1CA2CA12 | |
| SCHEMBL30916109 | 0.83 | CA1 (0.57) | HSD17B1HSD17B2CA1CA2CA4 | |
| SCHEMBL3080605 | 0.83 | CA1 (0.57) | HSD17B1HSD17B2CA1CA2CA4 | |
| SCHEMBL2677305 | 0.81 | DYRK1A (0.54) | HSD17B1HSD17B2GAAHTTMAOB | |
| SCHEMBL2656824 | 0.81 | GFER (0.57) | HSD17B1HSD17B2GAAHTTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0379716-B1 | Chemiluminescent 1,2-dioxetane compounds | TROPIX INC (US) | 1996-03-13 | — | — | EP | claimed |
| US-5438146-A | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1995-08-01 | — | — | US | claimed |
| US-5068339-A | Labels for biomolecules | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1991-11-26 | — | — | US | claimed |
| EP-0379716-A1 | Chemiluminescent 1,2-dioxetane compounds | TROPIX, INC. (US) | 1990-08-01 | — | — | EP | claimed |
| WO-1990007511-A1 | ENHANCED CHEMILUMINESCENCE FROM 1,2-DIOXETANES THROUGH ENERGY TRANSFER TO TETHERED FLUORESCERS | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 1990-07-12 | — | — | WO | claimed |
| US-7632952-B2 | 4-(2-hydroxy-2-methylpropylamino)benzenesulfonic acid 2-[(piperidine-4-carbonyl)-amino]benzothiazol-6-yl ester; anticancer activity, via modulation of the activity of proteins, in particular of kinases; anticarcinogenic agent | AVENTIS PHARMA S.A. (FR) | 2009-12-15 | — | — | US | disclosed |
| US-20070093488-A1 | Novel Benzothiazoles And The Use Thereof As Medicaments | AVENTIS PHARMA S.A. (FR) | 2007-04-26 | — | — | US | disclosed |
| EP-1745044-A2 | BENZOTHIAZOLE DERIVATIVES HAVING CDK MODULATING ACTIVITY AND USE THEREOF AS ANTICANCER AGENTS | Aventis Pharma S.A. (FR) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005097787-A2 | NOVEL BENZOTHIAZOLES AND THE USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA S.A. (FR) | 2005-10-20 | — | — | WO | disclosed |
| US-20020007663-A1 | Method of introducing an in situant into a vapor compression system, especially useful for leak detection, as well as an apparatus for leak detection and a composition useful for leak detection | MAINSTREAM ENGINEERING CORPORATION | 2002-01-24 | — | — | US | disclosed |
| US-6327897-B1 | Method of introducing an in situant into a vapor compression system, especially useful for leak detection, as well as an apparatus for leak detection and a composition useful for leak detection | MAINSTREAM ENGINEERING CORPORATION | 2001-12-11 | — | — | US | disclosed |
| EP-0424465-B1 | PREPARATION AND USE OF FLUORESCENT BENZOTHIAZOLE DERIVATIVES | JBL SCIENT INC (US) | 1997-10-29 | — | — | EP | disclosed |
| EP-0379716-B1 | Chemiluminescent 1,2-dioxetane compounds | TROPIX INC (US) | 1996-03-13 | — | — | EP | disclosed |
| US-5424440-A | A non-fluorescent detector when hydrolyzing with selected enzyme become fluorescent; colorimetric analysis, spectrophotometry | JBL SCIENTIFIC, INC. (US) | 1995-06-13 | — | — | US | disclosed |
| EP-0424465-A4 | PREPARATION AND USE OF FLUORESCENT BENZOTHIAZOLE DERIVATIVES | — | 1991-07-03 | — | — | EP | disclosed |
| EP-0424465-A1 | PREPARATION AND USE OF FLUORESCENT BENZOTHIAZOLE DERIVATIVES. | JBL SCIENT INC (US) | 1991-05-02 | — | — | EP | disclosed |
| WO-1990000618-A1 | PREPARATION AND USE OF FLUORESCENT BENZOTHIAZOLE DERIVATIVES | JBL SCIENTIFIC, INC. (US) | 1990-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093488-A1 | Novel Benzothiazoles And The Use Thereof As Medicaments | TFEB, ABAT, BRD4 | HSD17B1 3319/4885HSD17B2 2860/4885CA1 4534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.