Phosphoric Acid

Phosphoric Acid

SCHEMBL8773256

CC(N)(CO)CO.CC(N)(CO)CO.NC(=O)c1nc2ccc(O)cc2s1.O=P(O)(O)O

nearest known ligand 0.48

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Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MAOB P27338 16/20 0.48
HSD17B1 P14061 4/20 0.47
HSD17B2 P37059 4/20 0.47
MAPT P10636 1/20 0.46
SNCA P37840 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2B6 P20813 1/20 0.46
CYP2C19 P33261 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phosphoric Acid SCHEMBL8381672 0.89 HSD17B1 (0.57) MAOBHSD17B1HSD17B2MAPTSNCA
SCHEMBL31519036 0.83 HSD17B1 (0.63) MAOBHSD17B1HSD17B2MAPTSNCA
SCHEMBL4404844 0.83 HSD17B1 (0.63) MAOBHSD17B1HSD17B2MAPTSNCA
SCHEMBL8773258 0.83 MAPT (0.43) MAOBHSD17B1HSD17B2MAPT
SCHEMBL4402092 0.72 CA2 (0.59) MAOBHSD17B1HSD17B2CYP1A2CYP3A4
SCHEMBL4352378 0.71 HSD17B1 (0.67) MAOBHSD17B1HSD17B2MAPTSNCA
SCHEMBL3093869 0.70 RAB9A (0.57) MAOBMAPT
SCHEMBL8381667 0.69 MAOB (0.46) MAOBHSD17B1HSD17B2MAPT
SCHEMBL9050579 0.69 DYRK1A (0.61) MAOBHSD17B1HSD17B2MAPTSNCA
SCHEMBL9050628 0.69 HSD17B1 (0.63) MAOBHSD17B1HSD17B2MAPTSNCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0424465-B1 PREPARATION AND USE OF FLUORESCENT BENZOTHIAZOLE DERIVATIVES JBL SCIENT INC (US) 1997-10-29 EP disclosed
US-5424440-A A non-fluorescent detector when hydrolyzing with selected enzyme become fluorescent; colorimetric analysis, spectrophotometry JBL SCIENTIFIC, INC. (US) 1995-06-13 US disclosed