Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2671424 | 0.87 | ALOX5 (0.51) | ALOX5KIF11ACACBACACAKDM4E | |
| SCHEMBL4402967 | 0.87 | ALOX5 (0.51) | ALOX5KIF11SLC2A1ACACBACACA | |
| SCHEMBL4400592 | 0.83 | ALOX5 (0.47) | ALOX5KIF11ACACBACACAKDM4E | |
| SCHEMBL2671133 | 0.73 | KDM4E (0.52) | ALOX5KDM4EPARP1KMT2AALDH1A1 | |
| SCHEMBL30366673 | 0.72 | KIF11 (0.74) | KIF11HTR1AHTR1DHTR1BSLC2A1 | |
| SCHEMBL31506909 | 0.72 | KIF11 (0.74) | KIF11HTR1AHTR1DHTR1BSLC2A1 | |
| SCHEMBL2333579 | 0.72 | KIF11 (0.74) | KIF11HTR1AHTR1DHTR1BSLC2A1 | |
| SCHEMBL2056375 | 0.71 | ALOX5 (0.53) | ALOX5KIF11HTR1AHTR1DHTR1B | |
| SCHEMBL2054602 | 0.71 | ALOX5 (0.53) | ALOX5KIF11HTR1AHTR1DHTR1B | |
| SCHEMBL21156818 | 0.70 | LMNA (0.51) | KIF11HRH4KMT2ANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012056372-A1 | N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-05-03 | — | — | WO | disclosed |