SCHEMBL4405490

SCHEMBL4405490

COc1cc(-c2cc(=O)c3ccc(OCCCBr)cc3o2)cc(OC)c1OC

nearest known ligand 0.69

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PABPC1 P11940 1/20 0.63
BCHE P06276 1/20 0.56
ACHE P22303 1/20 0.56
ABCB1 P08183 1/20 0.56
CSNK2A2 P19784 2/20 0.54
CSNK2B P67870 2/20 0.54
CSNK2A1 P68400 2/20 0.54
MAOB P27338 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4411697 0.94 PABPC1 (0.64) PABPC1BCHEACHEABCB1CSNK2A2
SCHEMBL4399922 0.89 ABCB1 (0.72) BCHEACHEABCB1CSNK2A2CSNK2B
SCHEMBL4403604 0.87 BCHE (0.62) BCHEACHEMAOB
SCHEMBL6555693 0.84 PABPC1 (0.76) PABPC1ABCB1CSNK2A2CSNK2BCSNK2A1
SCHEMBL4414243 0.83 PABPC1 (0.60) PABPC1BCHEACHEABCB1CSNK2A2
SCHEMBL4542681 0.78 MEN1 (0.52) PABPC1
SCHEMBL4399496 0.77 PABPC1 (1.00) PABPC1ABCB1CSNK2A2CSNK2BCSNK2A1
SCHEMBL11101571 0.77 BCHE (0.48) BCHEACHEMAOB
SCHEMBL4550526 0.77 PABPC1 (0.51) PABPC1
SCHEMBL4408552 0.76 PABPC1 (0.57) PABPC1ABCB1CSNK2A2CSNK2BCSNK2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1807408-B1 OXY SUBSTITUTED FLAVONES AS ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC AGENTS COUNCIL SCIENT IND RES (IN) 2016-06-08 EP disclosed
US-7635779-B2 Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2009-12-22 US disclosed
EP-1807408-A1 OXY SUBSTITUTED FLAVONES AS ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC AGENTS Council of Scientific and Industrial Research (IN) 2007-07-18 EP disclosed
US-20060178373-A1 Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2006-08-10 US disclosed
WO-2006040621-A1 OXY SUBSTITUTED FLAVONES AS ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC AGENTS COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2006-04-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060178373-A1 Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents GPR119, LIPC, SLC5A2 PABPC1 4790/4885BCHE 744/4885ACHE 1224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.