⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22494209 | 0.80 | AKR1B1 (0.35) | — | |
| SCHEMBL329387 | 0.78 | — | — | |
| SCHEMBL28399588 | 0.77 | AKR1B1 (0.31) | — | |
| SCHEMBL31747939 | 0.77 | — | — | |
| SCHEMBL14659954 | 0.77 | — | — | |
| SCHEMBL4976456 | 0.76 | — | — | |
| SCHEMBL21670717 | 0.76 | CA2 (0.39) | — | |
| Hydrochloric Acid SCHEMBL3710347 | 0.76 | CA2 (0.39) | — | |
| SCHEMBL958579 | 0.76 | ALDH1A1 (0.39) | — | |
| SCHEMBL19913375 | 0.76 | TXNRD1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260116881-A1 | KIF MODULATOR COMPOUNDS AND METHODS OF USE | IAMBIC THERAPEUTICS INC (US) | 2026-04-30 | — | — | US | disclosed |
| WO-2025081019-A1 | KIF MODULATOR COMPOUNDS AND METHODS OF USE | IAMBIC THERAPEUTICS, INC. (US) | 2025-04-17 | — | — | WO | disclosed |
| EP-4327809-A2 | TYK2 INHIBITORS AND USES THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2024-02-28 | — | — | EP | disclosed |
| EP-3344624-B1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI INC (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2023134765-A1 | FIVE-MEMBERED-RING-CONTAINING DERIVATIVES, PREPARATION METHOD THEREFOR, AND USES THEREOF | 上海翰森生物医药科技有限公司 | 2023-07-20 | — | — | WO | disclosed |
| US-20230192666-A1 | PIPERAZINE INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS | CORCEPT THERAPEUTICS INCORPORATED | 2023-06-22 | — | — | US | disclosed |
| CN-110678177-B | Pyrazole MAGL inhibitors | H.隆德贝克有限公司 | 2023-06-13 | — | — | CN | disclosed |
| US-20210047319-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-02-18 | — | — | US | disclosed |
| US-10781204-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2020-09-22 | — | — | US | disclosed |
| US-10023571-B2 | TYK2 inhibitors and uses thereof | Nimbus Lakshimi, Inc. (US) | 2018-07-17 | — | — | US | disclosed |
| CN-101687877-A | Heterocyclic cyclopamine analogs and methods of use thereof | INFINITY DISCOVERY INC | 2010-03-31 | — | — | CN | disclosed |
| US-7648994-B2 | Heterocyclic cyclopamine analogs and methods of use thereof | INFINITY DISCOVERY, INC. (US) | 2010-01-19 | — | — | US | disclosed |
| EP-2129677-A1 | HETEROCYCLIC CYCLOPAMINE ANALOGS AND METHODS OF USE THEREOF | Infinity Discovery, Inc. (US) | 2009-12-09 | — | — | EP | disclosed |
| US-20080293755-A1 | Steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer and psoriasis | INFINITY DISCOVERY, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2008109184-A1 | HETEROCYCLIC CYCLOPAMINE ANALOGS AND METHODS OF USE THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2008-09-12 | — | — | WO | disclosed |
| CN-101255142-A | 2-substituted sulfinyl-5-(3,4,5-trialkoxy phenyl)-1,3,4-oxadiazole derivatives as well as preparation method and uses thereof | UNIV GUIZHOU (CN) | 2008-09-03 | — | — | CN | disclosed |
| EP-0946508-A1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | Du Pont Pharmaceuticals Company (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028269-A1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-07-02 | — | — | WO | disclosed |
| EP-0352944-B1 | Derivatives of N-phenylpyrazoles | RHONE POULENC AGRICULTURE (GB) | 1995-03-01 | — | — | EP | disclosed |
| EP-0352944-A1 | Derivatives of N-phenylpyrazoles | RHONE-POULENC AGRICULTURE LIMITED (GB) | 1990-01-31 | — | — | EP | disclosed |