Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4295259 | 0.89 | DGAT1 (0.61) | DGAT1EPHX2KMT2AKDM4EALDH1A1 | |
| SCHEMBL4406451 | 0.86 | DGAT1 (0.52) | DGAT1EPHX2CYP2C9CYP2C19CYP2J2 | |
| SCHEMBL4407981 | 0.86 | DGAT1 (0.47) | DGAT1EPHX2ALDH1A1KLKB1SCN9A | |
| SCHEMBL4409346 | 0.77 | TRPV1 (0.46) | DGAT1EPHX2SCN9A | |
| SCHEMBL13611480 | 0.76 | DGAT1 (0.65) | DGAT1EPHX2KMT2AKDM4EALDH1A1 | |
| SCHEMBL4291779 | 0.76 | DGAT1 (0.67) | DGAT1EPHX2CYP2C9CYP2C19CYP2J2 | |
| SCHEMBL4294183 | 0.75 | DGAT1 (0.61) | DGAT1EPHX2ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4289342 | 0.73 | TNFSF11 (0.61) | DGAT1EPHX2KMT2ACYP2C9CYP2C19 | |
| SCHEMBL4401623 | 0.71 | DGAT1 (0.57) | DGAT1EPHX2ALDH1A1SCN9APDCD1 | |
| SCHEMBL4302935 | 0.69 | DGAT1 (0.62) | DGAT1EPHX2CYP2C9CYP2C19CYP2J2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044055-A2 | AMIDE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-04-08 | — | — | EP | claimed |
| WO-2008011131-A2 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-24 | — | — | WO | claimed |
| EP-2044055-A2 | AMIDE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008011131-A2 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-24 | — | — | WO | disclosed |