Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | PRNP | P04156 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20936807 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2L3MBTL1HTTKMT2AMEN1 | |
| SCHEMBL20937165 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2L3MBTL1HTTKMT2AMEN1 | |
| SCHEMBL15533892 | 0.77 | KDM4E (0.56) | SMN1; SMN2L3MBTL1HTTKMT2AMEN1 | |
| SCHEMBL5629234 | 0.76 | KCNQ3 (0.60) | SMN1; SMN2L3MBTL1HTTALDH1A1RAB9A | |
| SCHEMBL1742541 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2L3MBTL1HTTKMT2AMEN1 | |
| SCHEMBL3712178 | 0.76 | KMT2A (0.59) | SMN1; SMN2L3MBTL1HTTKMT2AMEN1 | |
| SCHEMBL31056870 | 0.75 | ALDH1A1 (0.48) | SMN1; SMN2L3MBTL1KMT2AKDM4EALDH1A1 | |
| SCHEMBL29324953 | 0.75 | ALDH1A1 (0.48) | SMN1; SMN2L3MBTL1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22445716 | 0.74 | LDHA (0.61) | SMN1; SMN2L3MBTL1HTTKMT2AMEN1 | |
| SCHEMBL4393221 | 0.74 | MEN1 (0.73) | SMN1; SMN2L3MBTL1HTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2133340-B1 | Novel benzazepine derivatives | GLAXO GROUP LTD (GB) | 2013-01-16 | — | — | EP | disclosed |
| EP-2133340-A1 | Novel benzazepine derivatives | Glaxo Group Limited (GB) | 2009-12-16 | — | — | EP | disclosed |
| CN-1326838-C | Benzo[d]azepine derivatives for the treatment of neurological disorders | GLAXO GROUP LTD (GB) | 2007-07-18 | — | — | CN | disclosed |
| CN-1726042-A | Benzo[d]azepine derivatives for the treatment of neurological disorders | GLAXO GROUP LTD (GB) | 2006-01-25 | — | — | CN | disclosed |