Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.35 |
| ▸ | IDH1 | O75874 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.32 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440762 | 1.00 | MTNR1A (0.41) | MTNR1AMTNR1BHCRTR1HCRTR2SMYD3 | |
| Trifluoroacetic Acid SCHEMBL438004 | 0.93 | MTNR1A (0.37) | MTNR1AMTNR1BHCRTR1HCRTR2SMYD3 | |
| SCHEMBL2596218 | 0.84 | HCRTR1 (0.41) | MTNR1AMTNR1BHCRTR1HCRTR2SMYD3 | |
| SCHEMBL443068 | 0.82 | KMT2A (0.39) | MTNR1AMTNR1BHCRTR1HCRTR2HTT | |
| SCHEMBL443067 | 0.82 | KMT2A (0.39) | MTNR1AMTNR1BHCRTR1HCRTR2HTT | |
| SCHEMBL438019 | 0.78 | HCRTR1 (0.44) | HCRTR1HCRTR2IDH1NR1H4 | |
| SCHEMBL408844 | 0.78 | HCRTR1 (0.44) | HCRTR1HCRTR2IDH1NR1H4 | |
| SCHEMBL408884 | 0.77 | HCRTR1 (0.42) | HCRTR1HCRTR2IDH1ADORA1NR1H4 | |
| SCHEMBL408799 | 0.77 | HCRTR1 (0.42) | HCRTR1HCRTR2IDH1ADORA1NR1H4 | |
| SCHEMBL439231 | 0.77 | MTNR1A (0.42) | MTNR1AMTNR1BCCR5LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065196-A1 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-15 | — | — | US | disclosed |
| US-20120065196-A1 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065196-A1 | AMIDE COMPOUNDS | DGAT2, DGAT1, DLAT | MTNR1A 1862/4885MTNR1B 1684/4885HCRTR1 1535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.