Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417658 | 0.86 | MAPT (0.42) | MAPTTDP1SMN1; SMN2TP53RXFP1 | |
| SCHEMBL4416273 | 0.86 | MAPK14 (0.41) | MAPTTP53RXFP1TRPV1MAPK14 | |
| SCHEMBL4417279 | 0.86 | MAPT (0.41) | MAPTSMN1; SMN2TP53RXFP1TRPV1 | |
| SCHEMBL4410922 | 0.84 | MAPT (0.49) | MEN1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL4408412 | 0.81 | MAPK14 (0.44) | MAPTPOLBSMN1; SMN2TP53MAPK14 | |
| SCHEMBL5496963 | 0.80 | MAPK14 (0.44) | MAPTPOLBSMN1; SMN2MAPK14SMO | |
| SCHEMBL14534669 | 0.80 | MAPK14 (0.44) | MAPTPOLBSMN1; SMN2MAPK14SMO | |
| SCHEMBL4408195 | 0.80 | PARP10 (0.48) | MAPTPOLBSMN1; SMN2MAPK14SMO | |
| SCHEMBL5480560 | 0.80 | MEN1 (0.52) | MEN1KMT2AMAPTPOLBTDP1 | |
| SCHEMBL5487370 | 0.79 | MAPK14 (0.44) | MAPK14SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |