Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | AHR | P35869 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | SMO | Q99835 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14534467 | 0.87 | NR1H4 (0.49) | NR1H4PPARGPPARAMEN1KMT2A | |
| SCHEMBL4417658 | 0.86 | MAPT (0.42) | MAPTTP53PDE5AHDAC11HDAC8 | |
| SCHEMBL4408412 | 0.85 | MAPK14 (0.44) | MAPTTP53SMN1; SMN2MAPK14SMO | |
| SCHEMBL4417279 | 0.85 | MAPT (0.41) | MAPTTP53PDE5AHDAC11HDAC8 | |
| SCHEMBL4407832 | 0.84 | MEN1 (0.47) | MAPTTP53RXFP1SMN1; SMN2KDM4E | |
| SCHEMBL5496963 | 0.84 | MAPK14 (0.44) | MAPTSMN1; SMN2MAPK14SMOPOLB | |
| SCHEMBL4416273 | 0.84 | MAPK14 (0.41) | MAPTTP53RXFP1MAPK14SMO | |
| SCHEMBL14534669 | 0.83 | MAPK14 (0.44) | MAPTSMN1; SMN2MAPK14SMOPOLB | |
| SCHEMBL4408195 | 0.83 | PARP10 (0.48) | MAPTSMN1; SMN2MAPK14SMOPOLB | |
| SCHEMBL4410077 | 0.82 | MAPK14 (0.43) | MAPTSMN1; SMN2NR1H4MAPK14SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |