Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.40 |
| ▸ | SMO | Q99835 | 4/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4416273 | 0.90 | MAPK14 (0.41) | MAPTTP53RXFP1MAPK14SMO | |
| SCHEMBL4417279 | 0.87 | MAPT (0.41) | MAPTTP53RXFP1MAPK14SMO | |
| SCHEMBL4407832 | 0.86 | MEN1 (0.47) | MAPTTP53RXFP1MAPK14SMO | |
| SCHEMBL5487370 | 0.86 | MAPK14 (0.44) | MAPK14SMOGSK3AKCNH2 | |
| SCHEMBL4410922 | 0.86 | MAPT (0.49) | MAPTTP53RXFP1MAPK14SMO | |
| SCHEMBL4408412 | 0.83 | MAPK14 (0.44) | MAPTTP53MAPK14SMOSMN1; SMN2 | |
| SCHEMBL5496963 | 0.82 | MAPK14 (0.44) | MAPTMAPK14SMOSMN1; SMN2KCNH2 | |
| SCHEMBL2842154 | 0.81 | MAPK14 (0.45) | MAPK14SMOSRCGSK3ASYK | |
| SCHEMBL5486377 | 0.81 | MAPK14 (0.44) | MAPK14SMOKCNH2 | |
| SCHEMBL14534669 | 0.81 | MAPK14 (0.44) | MAPTMAPK14SMOSMN1; SMN2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |